Our front cover features Toll-like receptor 2 (TLR2; red) expression by satellite glial cells (SGC) in a human trigeminal ganglion (TG). Sensory ganglia, including TG, contain neuronal cell bodies tightly enwrapped by a sheet of SGC that provide physical support and a protective barrier. The image is taken from Mitterreiter et al. (pp. 1181–1187), where the authors compared side-by-side the expression and functionality of TLR1-9 on SGC and microglia isolated from human TG and brain tissue, respectively. Both cell types expressed an analogous TLR repertoire and cytokine response to TLR ligands, strengthening the role of SGC as local antigen presenting cells that orchestrate ganglionic immune responses in pathogen defense and chronic pain.
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