Breast Cancer: Biology or Stage?

A 44-year-old woman was found to have 2 groups of calcifications within the left breast on routine screening mammogram: one at 2 o'clock measuring 28 mm and a second at 3 o'clock measuring 40 mm. Follow-up diagnostic mammogram confirmed multiple groups of pleomorphic calcifications spanning >7 cm in the upper outer quadrant. Stereotactic core needle biopsy noted invasive carcinoma, predominantly lobular type, grade 2, estrogen receptor positive (Allred 8), progesterone receptor positive (Allred 8), HER2 negative (0) at the 2 o'clock site; and ductal carcinoma in situ without invasion at 3 o'clock.

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