A novel sclerosing atypical lipomatous tumor/well-differentiated liposarcoma in a 7-year-old girl: Report of a case with molecular confirmation

Atypical lipomatous tumor/well-differentiated liposarcoma/dedifferentiated liposarcoma (ALT/WDL/DDL) is a common type of liposarcoma in late adulthood. However, pediatric ALT/WDL/DDL is extremely rare, and only 3 cases have been described in children younger than 10years of age. Notably, none of these cases harbored MDM2 gene amplification. Here, we reported a sclerosing ALT/WDL in a 7-year-old Chinese girl. Histologically, in most areas, the neoplastic cells were embedded within the collagenous background and typical lipogenic areas were inconspicuous throughout the sclerotic areas.

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