“Riddle Me This”: Substrate Channeling Solves the Paradigms of cAMP-Dependent Activation of PKA

Cell signaling is a cascade of events that coordinates proper responses in cells upon sensing an external stimulus available in their surroundings. The ability of cells to respond to these highly dynamic changes in their immediate environment is what enables larger, coordinated responses that range from population control in bacterial communities to tissue development and homeostasis in multicellular organisms. Conversely, deregulation of cell signaling leads to lack of this homeostasis; in humans, it can lead to severe diseases.

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