Concurrent Neoadjuvant Chemotherapy and Radiotherapy in Locally Advanced Breast Cancer

This prospective phase II trial recruited thirty-two patients with locally advanced breast cancer to receive neoadjuvant radiosensitizing chemotherapy with concurrent radiation. Patients were matched to a concurrent cohort treated with neoadjuvant chemotherapy, mastectomy then radiation. Patients showed significantly improved pathological complete response, but no statistically significant difference in survival. A prospective randomized trial is warranted using another radiosensitizer to exploit this improved response with reduced toxicity.

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