Relapse Rates with Surgery Alone in HPV-related Intermediate and High Risk Group Oropharynx Squamous Cell Cancer, A Multi-Institutional Review

Indications for adjuvant therapy including radiation therapy (RT) and chemotherapy after surgery for oropharyngeal squamous cell cancer (OPSCC) were defined prior to the predominance of human papilloma virus-related (HPV+) disease. Risk factors for relapse were likewise determined prior to the development of Transoral Surgery (TOS) such as transoral robotic surgery (TORS) and transoral laser microsurgery (TLM). This study aimed to evaluate whether historic risk categories and indications for adjuvant therapy in the pre-HPV and pre-TOS era were associated with clinically significant relapse rates in HPV+ OPSCC patients undergoing TOS.

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