Clinical Outcomes of Large Brain Metastases Treated with Neurosurgical Resection and Intraoperative Cesium-131 Brachytherapy: Results of a Prospective Trial

Treating brain metastases ≥2 cm with radiation remains a challenge. Results from traditional techniques such as stereotactic radiosurgery are worse with larger lesions compared to smaller lesions. Here we present an alternative technique to treat large brain metastases using neurosurgical resection and intraoperative brachytherapy using a novel radioisotope, Cesium-131. Our study presents evidence that Cesium-131 results in high rates of local control, minimizes the risk of radionecrosis, and represents a safe and effective adjuvant therapy.

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