Bright and photostable fluorescent probe with aggregation-induced emission characteristics for specific lysosome imaging and tracking

Publication date: 1 October 2016
Source:Talanta, Volume 159
Author(s): Jiang Ouyang, Qiguang Zang, Wansong Chen, Liqiang Wang, Shuo Li, Ren-Yu Liu, Yuanyuan Deng, Zhao-Qian Liu, Juan Li, Liu Deng, You-Nian Liu
We develop a new lysosome-targeting AIE fluorescent probe tetraphenylethene-morpholine (TPE-MPL), by incorporating a typical lysosome-targeting moiety of morpholine into a stable tetraphenylethene skeleton. Due to both the AIE and antenna effects, TPE-MPL possesses superior photostability, appreciable tolerance to microenvironment change and high lysosome targeting ability. Our findings confirm that TPE-MPL is a well-suited imaging agent for targeting lysosome and tracking dynamic movement of lysosome. Moreover, due to its synthetic accessibility, TPE-MPL could be further modified as a dual-functional probe for lysosome, thereby gain further insight into the role of lysosome in biomedical applications.

Graphical abstract

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