Helicobacter pylori (H. pylori), a major cause of gastroduodenal diseases, produces VacA, a vacuolating cytotoxin associated with gastric inflammation and ulceration. The C-terminal domain of VacA plays a crucial role in receptor recognition on target cells. We have previously identified three proteins (i.e., RPTPα, RPTPβ, and LRP1) that serve as VacA receptors. These receptors contribute to the internalization of VacA into epithelial cells, activate signal transduction pathways, and contribute to cell death and gastric ulceration. In addition, other factors (e.g., CD18, sphingomyelin) have also been identified as cell-surface, VacA-binding proteins. Since we believe that, following interactions with its host cell receptors, VacA participates in events leading to disease, a better understanding of the cellular function of VacA receptors may provide valuable information regarding the mechanisms underlying the pleiotropic actions of VacA and the pathogenesis of H. pylori-mediated disease. In this review, we focus on VacA receptors and their role in events leading to cell damage.
from #Medicine via ola Kala on Inoreader http://ift.tt/1R0Onzs
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαΐου
(630)
-
▼
Μαΐ 13
(50)
- Radiological response is associated with better lo...
- Does neighborhood fast-food outlet exposure amplif...
- The use of capsule endoscopy in the emergency depa...
- Association between severity of obstructive sleep ...
- Dysphagia in patients with acute ischemic stroke: ...
- Applicability of hepatitis C virus RNA viral load ...
- Management and outcomes of leaks after oesophagectomy
- Prevalence of overweight and obesity among childre...
- The inter-rater reliability of the International C...
- Cognitive reserve and preinjury educational attain...
- The relationship between static posturography meas...
- Kullback–Leibler divergence and the Pareto–Exponen...
- Carriage rate and methicillin resistance of Staphy...
- Expression of scavenger receptor A in rat’s liver ...
- Scientists’ personality, values, and well-being
- Aspergillus leaf spot of field bindweed (Convolvul...
- P53 and the defenses against genome instability ca...
- Issue Information
- Toxins, Vol. 8, Pages 150: Sensitive, Rapid, Quant...
- Toxins, Vol. 8, Pages 152: New Insights into VacA ...
- Toxins, Vol. 8, Pages 151: Ellagitannins in Cancer...
- Toxins, Vol. 8, Pages 149: Determination of Asymme...
- Sensors, Vol. 16, Pages 692: A Nonlinear Framework...
- Nanomaterials, Vol. 6, Pages 90: Aggregation and C...
- Energies, Vol. 9, Pages 365: Energy Performance of...
- JMSE, Vol. 4, Pages 34: Recent Advances in the Stu...
- Toxins, Vol. 8, Pages 152: New Insights into VacA ...
- Sustainability, Vol. 8, Pages 476: Importance of A...
- Sensors, Vol. 16, Pages 689: Comprehensive Compari...
- IJERPH, Vol. 13, Pages 499: Fever and Pain Managem...
- Toxins, Vol. 8, Pages 149: Determination of Asymme...
- Polymers, Vol. 8, Pages 163: The Effect of Lithium...
- Separations, Vol. 3, Pages 14: Method for the Dete...
- Hirnbasissyndrom infolge eines Tumors bei einer 17...
- Ahead of print: Niederfeld-magnetresonanztomograph...
- Paclitaxel-coated balloon fistuloplasty versus pla...
- Employment Outcomes After Critical Illness: An Ana...
- Vaccines, Vol. 4, Pages 17: Comprehensive Characte...
- Water, Vol. 8, Pages 198: A Methodology to Assess ...
- Forests, Vol. 7, Pages 107: Rating a Wildfire Miti...
- Resources, Vol. 5, Pages 19: Critical Minerals and...
- Algorithms, Vol. 9, Pages 33: Mining Branching Rul...
- Sensors, Vol. 16, Pages 691: Planar Position Senso...
- IJERPH, Vol. 13, Pages 498: Brazilian Green Propol...
- Medical Sciences, Vol. 4, Pages 10: First Evidence...
- Toxins, Vol. 8, Pages 150: Sensitive, Rapid, Quant...
- Metals, Vol. 6, Pages 112: Performances of Green a...
- Social Sciences, Vol. 5, Pages 19: Making Communic...
- Micromachines, Vol. 7, Pages 90: A Comprehensive R...
- Fluids, Vol. 1, Pages 15: Modeling the Viscoelasti...
-
▼
Μαΐ 13
(50)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Παρασκευή 13 Μαΐου 2016
Toxins, Vol. 8, Pages 152: New Insights into VacA Intoxication Mediated through Its Cell Surface Receptors
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.