Quercitrin is a well-known flavonoid that is contained in Flos Albiziae, which has been used for the treatment of anxiety. The present study investigated the anxiolytic-like effects of quercitrin in experimental models of anxiety. Compared with the control group, repeated treatment with quercitrin (5.0 and 10.0 mg/kg/day, p.o.) for seven days significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze. In the light/dark box test, quercitrin exerted an anxiolytic-like effect at 5 and 10 mg/kg. In the marble-burying test, quercitrin (5.0 and 10.0 mg/kg) also exerted an anxiolytic-like effect. Furthermore, quercitrin did not affect spontaneous locomotor activity. The anxiolytic-like effects of quercitrin in the elevated plus maze and light/dark box test were blocked by the serotonin-1A (5-hydroxytryptamine-1A (5-H)) receptor antagonist WAY-100635 (3.0 mg/kg, i.p.) but not by the γ-aminobutyric acid-A (GAB) receptor antagonist flumazenil (0.5 mg/kg, i.p.). The levels of brain monoamines (5-HT and dopamine) and their metabolites (5-hydroxy-3-indoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid) were decreased after quercitrin treatment. These data suggest that the anxiolytic-like effects of quercitrin might be mediated by 5-H receptors but not by benzodiazepine site of GAB receptors. The results of the neurochemical studies suggest that these effects are mediated by modulation of the levels of monoamine neurotransmitters.
from #Medicine via ola Kala on Inoreader http://ift.tt/1sAVOKb
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Μαΐου
(630)
-
▼
Μαΐ 19
(50)
- Water, Vol. 8, Pages 210: Water Governance Decentr...
- Involvement of 5-HT1A Receptors in the Anxiolytic-...
- Nutrients, Vol. 8, Pages 300: Dietary Patterns in ...
- Lubricants, Vol. 4, Pages 15: Pleural Lubrication
- Materials, Vol. 9, Pages 388: Evaluation of Micros...
- Sensors, Vol. 16, Pages 724: A Continuous Liquid-L...
- Energies, Vol. 9, Pages 383: An Intelligent Sensor...
- Energies, Vol. 9, Pages 384: Cobalt-Based Electrol...
- END-PROCESSING NUCLEASES AND PHOSPHODIESTERASES: A...
- ALKBHs-facilitated RNA modifications and de-modifi...
- Polymers, Vol. 8, Pages 200: Thermogel-Coated Poly...
- Energies, Vol. 9, Pages 385: A Study on Price-Base...
- Materials, Vol. 9, Pages 392: Optimising Ambient S...
- Materials, Vol. 9, Pages 390: Influence of Hybridi...
- Sustainability, Vol. 8, Pages 491: Abandonment, Ec...
- Sensors, Vol. 16, Pages 729: Systematic Error Mode...
- Applied Sciences, Vol. 6, Pages 157: Chord Recogni...
- Crystals, Vol. 6, Pages 61: Colloidal Photonic Cry...
- Energies, Vol. 9, Pages 386: Modelling, Testing an...
- A systematic review of community based hepatitis C...
- On-treatment HCV RNA as a predictor of sustained v...
- Hepatitis B virus expression and replication in ov...
- A phase II study of a modified FOLFOX6 regimen as ...
- Preclinical development of Ramizol, an antibiotic ...
- Efficacy of double-coated probiotics for irritable...
- Intensity of adjuvant chemotherapy regimens and gr...
- Design of a multicentre randomized controlled tria...
- An open-label randomized control study to compare ...
- Development of an angiogenesis-promoting microvesi...
- Cloning and expression analysis of cinnamoyl-CoA r...
- Sensors, Vol. 16, Pages 728: 1-RAAP: An Efficient ...
- IJGI, Vol. 5, Pages 72: Density-Based Clustering w...
- Pharmaceuticals, Vol. 9, Pages 27: Pharmacologic E...
- Marine Drugs, Vol. 14, Pages 100: Impact of Microa...
- Entropy, Vol. 18, Pages 190: Specific Differential...
- Sensors, Vol. 16, Pages 725: The Conceptual Design...
- Entropy, Vol. 18, Pages 192: Common Probability Pa...
- Sensors, Vol. 16, Pages 714: Error Ellipsoid Analy...
- Energies, Vol. 9, Pages 381: An Event-Triggered On...
- Sinusitis, Vol. 1, Pages 65-75: LTD4 and TGF-β1 In...
- Pharmaceuticals, Vol. 9, Pages 28: Targeted Therap...
- Energies, Vol. 9, Pages 380: Analysis and Minimiza...
- Polymers, Vol. 8, Pages 188: Repair Effect of Seaw...
- Religions, Vol. 7, Pages 55: Congregations and Soc...
- Marine Drugs, Vol. 14, Pages 102: Axonal Transport...
- Energies, Vol. 9, Pages 382: Comparative Study of ...
- Sensors, Vol. 16, Pages 709: A Low-Noise Transimpe...
- JCM, Vol. 5, Pages 54: Comparison of Intravenous A...
- Randomized Trial of a Lifestyle Program in Obese I...
- Danazol Treatment for Telomere Diseases
-
▼
Μαΐ 19
(50)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 19 Μαΐου 2016
Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.