Copy number variations (CNVs) have attracted increasing evidences to represent their roles as cancer susceptibility regulators. However, little is known about the role of CNV in epithelia ovarian cancer (EOC). Recently, the CNV-67048 of WW domain-containing oxidoreductase (WWOX) was reported to alter cancer risks. Considering that WWOX also plays a role in EOC, we hypothesized that the CNV-67048 was associated with EOC risk. In a case-control study of 549 EOC patients and 571 age (±5 years) matched cancer-free controls, we found that the low copy number of CNV-67048 (1-copy and 0-copy) conferred a significantly increased risk of EOC (OR = 1.346, 95% CI = 1.037–1.747) and it determined the risk by means of copy number-dependent dosage effect (). Data from TCGA also confirmed the abovementioned association as the frequency of low copies in EOC group was 3.68 times more than that in healthy group (). The CNV also negatively interacted with oral contraceptive use on EOC risk (). Functional analyses further showed a lower mRNA level of WWOX in tissues with the 0-copy or 1-copy than that in those with the 2-copy (). Our data suggested the CNV-67048 to be a risk factor of EOC in Chinese women.
from #Medicine via ola Kala on Inoreader http://ift.tt/1S4GAon
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Απριλίου
(500)
-
▼
Απρ 11
(51)
- Retrospective cohort study of cancer incidence and...
- Research priorities for shoulder surgery: results ...
- Objectively measured physical activity and sedenta...
- Quantifying the regional variations in the mechani...
- The effect of modulating top-down attention deploy...
- The Perseverative Worry Bout: A Review of Cognitiv...
- Marginal value theorem, patch choice, and human fo...
- The Impact of a Low Glycemic Index Diet on Inflamm...
- Adipose Tissue Dysfunction: Clinical Relevance and...
- Biases in grant proposal success rates, funding ra...
- Distributions of p-values smaller than .05 in psyc...
- How we see electronic games
- Autophagy downregulation contributes to insulin re...
- Involvement of the arachidonic acid cytochrome P45...
- Connecting laboratory behavior to field function t...
- Differences in stability of seed-associated microb...
- ROCK activity regulates functional tight junction ...
- Assessment of the accuracy of ABC/2 variations in ...
- Effects of combined physical education and nutriti...
- WWOX CNV-67048 Functions as a Risk Factor for Epit...
- Phenotypic Variation in Patients with Chronic Obst...
- Metabolomic and proteomic analysis of serum from p...
- The effect of aspirin and nonsteroidal anti-inflam...
- Yttrium-90 Microsphere Brachytherapy for Liver Met...
- Rabeprazole, minocycline, amoxicillin, and bismuth...
- Access to subspecialty care and survival among pat...
- Trends in the use of endoscopic retrograde cholang...
- Is the prevalence of colonic neuroendocrine tumors...
- Diagnostic yield of 24-hour esophageal manometry i...
- Multiple siRNAs against HCV and host genes are mor...
- Population attributable fractions of risk factors ...
- Glycemic index and glycemic load and risk of color...
- High-dose hepatitis B immunoglobulin therapy in he...
- Endoscopic and histologic response to cyclosporine...
- Membrane localization of human equilibrative nucle...
- Macrophage activation marker, soluble CD163 is an ...
- Fatty Liver, Insulin Resistance, and Obesity: Rela...
- Vascularizing lymph node dissection for advanced g...
- Is the Stretta procedure as effective as the best ...
- The benefit of chemotherapy in esophageal cancer p...
- Gut microbiota profiling of pediatric NAFLD and ob...
- Economies, Vol. 4, Pages 6: Nonlinear Monetary Pol...
- Molbank, Vol. 2016, Article M894: 1-[2-(4-Methyl-7...
- Nanomaterials, Vol. 6, Pages 66: Automatic Echogra...
- Sensors, Vol. 16, Pages 519: Sample-Wise Aiding in...
- Toxins, Vol. 8, Pages 103: Comparison of Enzyme-Li...
- Remote Sensing, Vol. 8, Pages 319: Mapping a Knowl...
- Atmosphere, Vol. 7, Pages 54: Exposure to Particle...
- Challenges, Vol. 7, Pages 8: Policies Supporting R...
- Sensors, Vol. 16, Pages 515: Asymmetric Directiona...
- Sinusitis, Vol. 1, Pages 55-64: Fatty Acid Composi...
-
▼
Απρ 11
(51)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 11 Απριλίου 2016
WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.