Aim of this work was to investigate the automatic echographic detection of an experimental drug delivery agent, halloysite clay nanotubes (HNTs), by employing an innovative method based on advanced spectral analysis of the corresponding "raw" radiofrequency backscatter signals. Different HNT concentrations in a low range (5.5–66 × 1010 part/mL, equivalent to 0.25–3.00 mg/mL) were dispersed in custom-designed tissue-mimicking phantoms and imaged through a clinically-available echographic device at a conventional ultrasound diagnostic frequency (10 MHz). The most effective response (sensitivity = 60%, specificity = 95%), was found at a concentration of 33 × 1010 part/mL (1.5 mg/mL), representing a kind of best compromise between the need of enough particles to introduce detectable spectral modifications in the backscattered signal and the necessity to avoid the losses of spectral peculiarity associated to higher HNT concentrations. Based on theoretical considerations and quantitative comparisons with literature-available results, this concentration could also represent an optimal concentration level for the automatic echographic detection of different solid nanoparticles when employing a similar ultrasound frequency. Future dedicated studies will assess the actual clinical usefulness of the proposed approach and the potential of HNTs for effective theranostic applications.
from #Medicine via ola Kala on Inoreader http://ift.tt/1VhIwx6
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
▼
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
-
▼
Απριλίου
(500)
-
▼
Απρ 11
(51)
- Retrospective cohort study of cancer incidence and...
- Research priorities for shoulder surgery: results ...
- Objectively measured physical activity and sedenta...
- Quantifying the regional variations in the mechani...
- The effect of modulating top-down attention deploy...
- The Perseverative Worry Bout: A Review of Cognitiv...
- Marginal value theorem, patch choice, and human fo...
- The Impact of a Low Glycemic Index Diet on Inflamm...
- Adipose Tissue Dysfunction: Clinical Relevance and...
- Biases in grant proposal success rates, funding ra...
- Distributions of p-values smaller than .05 in psyc...
- How we see electronic games
- Autophagy downregulation contributes to insulin re...
- Involvement of the arachidonic acid cytochrome P45...
- Connecting laboratory behavior to field function t...
- Differences in stability of seed-associated microb...
- ROCK activity regulates functional tight junction ...
- Assessment of the accuracy of ABC/2 variations in ...
- Effects of combined physical education and nutriti...
- WWOX CNV-67048 Functions as a Risk Factor for Epit...
- Phenotypic Variation in Patients with Chronic Obst...
- Metabolomic and proteomic analysis of serum from p...
- The effect of aspirin and nonsteroidal anti-inflam...
- Yttrium-90 Microsphere Brachytherapy for Liver Met...
- Rabeprazole, minocycline, amoxicillin, and bismuth...
- Access to subspecialty care and survival among pat...
- Trends in the use of endoscopic retrograde cholang...
- Is the prevalence of colonic neuroendocrine tumors...
- Diagnostic yield of 24-hour esophageal manometry i...
- Multiple siRNAs against HCV and host genes are mor...
- Population attributable fractions of risk factors ...
- Glycemic index and glycemic load and risk of color...
- High-dose hepatitis B immunoglobulin therapy in he...
- Endoscopic and histologic response to cyclosporine...
- Membrane localization of human equilibrative nucle...
- Macrophage activation marker, soluble CD163 is an ...
- Fatty Liver, Insulin Resistance, and Obesity: Rela...
- Vascularizing lymph node dissection for advanced g...
- Is the Stretta procedure as effective as the best ...
- The benefit of chemotherapy in esophageal cancer p...
- Gut microbiota profiling of pediatric NAFLD and ob...
- Economies, Vol. 4, Pages 6: Nonlinear Monetary Pol...
- Molbank, Vol. 2016, Article M894: 1-[2-(4-Methyl-7...
- Nanomaterials, Vol. 6, Pages 66: Automatic Echogra...
- Sensors, Vol. 16, Pages 519: Sample-Wise Aiding in...
- Toxins, Vol. 8, Pages 103: Comparison of Enzyme-Li...
- Remote Sensing, Vol. 8, Pages 319: Mapping a Knowl...
- Atmosphere, Vol. 7, Pages 54: Exposure to Particle...
- Challenges, Vol. 7, Pages 8: Policies Supporting R...
- Sensors, Vol. 16, Pages 515: Asymmetric Directiona...
- Sinusitis, Vol. 1, Pages 55-64: Fatty Acid Composi...
-
▼
Απρ 11
(51)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Δευτέρα 11 Απριλίου 2016
Nanomaterials, Vol. 6, Pages 66: Automatic Echographic Detection of Halloysite Clay Nanotubes in a Low Concentration Range
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.