Multiple human papillomavirus infections and type-competition in woman from a clinic attendee population in China

Abstract

To investigate the multi-infection patterns and type competition for human papillomavirus (HPV) in Chinese clinic attending women and evaluate the association between the infection status and cancer risk.332 HPV-DNA-positive samples were genotyped for 21 HPVs and tested for 13 types of HPV neutralizing antibody using pseudoviron-based assay. Odds ratios (ORs) were calculated to evaluate the coinfection patterns for both DNA and neutralizing antibody (NAb), and the associations of HSIL + with HPV DNA and NAb. Of the 332 HPV-DNA-positive subjects, 279 (84.0%) were detected as NAb positive. Multi-positive results were identified in 23.2% (77/332) HPV DNA tests and 60.2% (168/279) HPV NAb assays. The NAb titers for the multiple-positive samples (geometric mean 214) were significantly higher than the single-positive samples (geometric mean 114) (p < 0.01). HPV16-HPV52 was identified as a type-competition pair for both HPV DNA (OR= 0.09; 95% CI = 0.02-0.42) and NAb (OR= 0.27; 95% CI = 0.11-0.69) data. Compared to other types, HPV16 DNA was associated significantly with high risk of HSIL+ (OR= 2.57; 95% CI = 1.23-5.38).HPV16-HPV52 was identified as a potential type-competition pair, which might result in the type modulation with the implementation of the approved bi-or quadri-valent vaccines. This article is protected by copyright. All rights reserved

from #Medicine via ola Kala on Inoreader http://ift.tt/1qtr0tI
via IFTTT