Evaluating the Microcirculation of Normal Extraocular Muscles Using Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging.

Purpose: The purpose of this work was to evaluate the microcirculation of normal extraocular muscles using quantitative dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) (DCE-MRI). Materials and Methods: The institutional review board approved the study. Forty-eight eyes were examined using quantitative DCE-MRI on a 3-T MRI system. Quantitative parameters, including the volume transfer constant (K trans), the fractional volume of extravascular extracellular space (V e), and the rate constant (K ep) of each extraocular muscles, were analyzed. The type of DEC time-intensity curve (TIC) was evaluated. The parameters of bilateral extraocular muscles were compared using the Wilcoxon test. The difference in quantitative values of different extraocular muscles was compared using independent-samples Kruskal-Wallis test. Results: No statistical differences of parameters were found between the left and right extraocular muscles (P > 0.05). Volume transfer constant values in medial rectus (MR) muscles and inferior rectus (IR) muscles were significantly higher than those in the lateral rectus (LR) muscles and superior rectus (SR) muscles (P 0.05). In the 4 extraocular muscles, the V e values of MR are the largest, followed by the IR, LR, and SR values. The DCE time-intensity curves of extraocular muscles are type II or type III. Medial rectus and IR are mainly type III, and LR and SR are mainly type II. Conclusion: The quantitative DCE-MRI can be used as an important and noninvasive technique to evaluate the microcirculation of extraocular muscles. Further investigations for other extraocular muscles diseases by using quantitative DCE-MRI are warranted. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

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