A highly immunogenic vaccine against A/H7N9 influenza virus

Publication date: 3 February 2016
Source:Vaccine, Volume 34, Issue 6
Author(s): Weiping Cao, Justine S. Liepkalns, Ahmed O. Hassan, Ram P. Kamal, Amelia R. Hofstetter, Samuel Amoah, Jin Hyang Kim, Adrian J. Reber, James Stevens, Jacqueline M. Katz, Shivaprakash Gangappa, Ian A. York, Suresh K. Mittal, Suryaprakash Sambhara
Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/H7N9 viral challenge suggesting its potential utility as a pandemic vaccine.



from #Medicine via ola Kala on Inoreader http://ift.tt/1ZLcuYj
via IFTTT