Abstract
Objective
To assess the utility of an intermediate ultrasound scan at 16+0 -18+6 weeks of gestation (WG) in euploid fetuses with increased nuchal translucency ≥ 3.5 mm.
Methods
389 fetuses with NT ≥ 3.5 mm were identified in two prenatal centers between January 2008 and December 2012. Pregnancy work-up included karyotyping, monthly detailed US scan starting with a 16 weeks scan, a cardioechography, and a genetic counseling. Abnormal findings and pregnancy outcomes were analysed retrospectively.
Results
Of the 389 fetuses included, 52% had normal karyotype. Among euploid fetuses, 51 (30.7%) structural defects were identified overall. First trimester scan was useful to identify sixteen of the major defects (31.3%), the 16th week scan an additional 21 of them (41.2%) whereas the 22nd week scan pregnancy scan discovered an additional 14 (27.4%). Structural defects discovered with the 16th week scan were cardiac defects (n = 7), polymalformative syndromes (n = 3), left diaphragmatic hernias (n = 3) limbs abnormalities (n = 2), genito-urinary (n = 2), microretrognathism (n = 2), hydrops (n = 1) and exomphalos (n = 1). If the intermediate scan was normal, the chances of a favorable outcome were as high as 85% and were closed to 100% after 20 weeks, irrespective of initial NT.
Conclusion
The intermediate ultrasound was useful in fetuses with increased NT pregnancy work-up.
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