High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography

The biomechanical properties of artery are primarily determined by the fibrous structures in the vessel wall. Many vascular diseases are associated with alternations in the orientation and alignment of the fibrous structure in the arterial wall. Knowledge on the structural features of the artery wall is crucial to our understanding of the biology of vascular diseases and the development of novel therapies. Optical coherence tomography (OCT) and polarization-sensitive OCT have shown great promise in imaging blood vessels due to their high resolution, fast acquisition, good imaging depth, and large field of view. However, the feasibility of using OCT based methods for imaging fiber orientation and distribution in the arterial wall has not been investigated. Here we show that the optical polarization tractography (OPT), a technology developed from Jones matrix OCT, can reveal the fiber orientation and alignment in the bovine common carotid artery. The fiber orientation and alignment data obtained in OPT provided a robust contrast marker to clearly resolve the intima and media boundary of the carotid artery wall.

The biomechanical properties of the artery are primarily determined by the fibrous structures in the vessel wall. This study demonstrated that optical polarization tractography (OPT) can visualize the 3D fiber architecture in the bovine common carotid artery. The fiber alignment profiles obtained in OPT provided a robust contrast marker to resolve the intima and media boundary of the carotid artery wall.

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