Background: Packed red blood cell (PRBC) transfusion is required in hematology patients treated with chemotherapy for acute leukemia, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT). In certain situations like septic shock, hip surgery, coronary disease or gastrointestinal hemorrhage, a restrictive transfusion strategy is associated with a reduction of infection and death. A transfusion strategy using a single PRBC unit has been retrospectively investigated and showed a safe reduction of PRBC consumption and costs. We therefore designed a study to prospectively demonstrate that the transfusion of a single PRBC unit is safe and not inferior to standard care. Methods: The 1versus2 trial is a randomized trial which will determine if a single-unit transfusion policy is not inferior to a double-unit transfusion policy. The primary endpoint is the incidence of severe complication (grade ≥ 3) defined as stroke, transient ischemic attack, acute coronary syndrome, heart failure, elevated troponin level, intensive care unit transfer, death, new pulmonary infiltrates, and transfusion-related infections during hospital stays. The secondary endpoint is the number of PRBC units transfused per patient per hospital stay. Two hundred and thirty patients will be randomized to receive a single unit or double unit every time the hemoglobin level is less than 8 g/dL. All patients admitted for induction remission chemotherapy, auto-HSCT or allo-HSCT in hematology intensive care units will be eligible for inclusion. Sample size calculation has determined that a patient population of 230 will be required to prove that the 1-unit PRBC strategy is non-inferior to the 2-unit PRBC strategy. Hemoglobin threshold for transfusion is below 8 g/dL. Estimated percentage of complication-free hospital stays is 93 %. In a non-inferiority hypothesis, the number of patients to include is 230 with a power of 90 % and an alpha risk of 5 %.Trial Registration14–128; Clinicaltrials.gov NCT02461264 (registered on 3 June 2015)
from #Medicine via ola Kala on Inoreader http://ift.tt/1N7naho
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 22
(68)
- Sensors, Vol. 15, Pages 29478-29510: TF4SM: A Fram...
- Topic shift impairs pronoun resolution during sent...
- Epigarcinol and isogarcinol isolated from the root...
- Parental knowledge and practices on infant teethin...
- Ageing and gastrointestinal sensory function: Alte...
- Development of an American Version of the Nottingh...
- A Partnership Between a Service Provider and Acade...
- Editorial Board
- Pre-Screening for Distress in Patients Prior to Un...
- Table of Contents
- Editors' Selections From This Issue: Volume 96 / N...
- WITHDRAWN
- Clinical Trial Registration: The Time Has Come…
- Cerebral Palsy: Association of Cranial Magnetic Re...
- Masthead
- The Effect of a Topical Alpha-Agonist on Fecal Inc...
- TUG and 2MWT: Important Functional Outcome Measure...
- Laryngectomees Experiences in the Health Care Syst...
- Concussion Symptoms in Adolescents Are Alleviated ...
- Impact of Coping Skills Intervention Group for Pat...
- Understanding the Nature of Home Exercise Programs...
- Archives Manuscript Reviewers
- 2015 ACRM Annual Conference Late-Breaking Research...
- Integration of Clinical and Research Neuroimaging ...
- Breast Cancer Survivors Self-Reported Symptoms and...
- Hospital-Based Rehabilitation for Recurrent Gliobl...
- Academy News
- Innovative Payment and Practice Models
- Spanish Translated Abstracts
- Isolation of a novel bio-peptide from walnut resid...
- Transfusion strategy in hematological intensive ca...
- Measuring DDLS in preperimetric glaucoma
- Geographic atrophy
- Cercopithecoid humeri from Taung support the disti...
- Identification of genes associated with melanoma m...
- Isolation and Compositional Analysis of Plant Cuti...
- Highlights from Gastro Update Europe: Budapest, Ju...
- Quadruple therapy versus standard triple therapy f...
- Switches of stimulus tagging frequencies interact ...
- Controversies in Pediatric Perioperative Airways
- Effects of Shared Electronic Health Record Systems...
- Comment on “Simulating Radiotherapy Effect in High...
- The Activation of Nrf2 and Its Downstream Regulate...
- The Composition, Antioxidant and Antibacterial Act...
- What is left of adaptive servo-ventilation after t...
- Implémentation d’un programme de soins oncologique...
- Adaptive servo-ventilation: How does it fit into t...
- On- and off-shell Jost functions and their integra...
- Transformation of bipartite non-maximally entangle...
- An Empirical Analysis of Moscovitch's Reconceptual...
- Theory of mind in social anxiety disorder, depress...
- Luteolin Exerts Cardioprotective Effects through I...
- Microchamber arrays with an integrated long lumine...
- Ho-Jin Song and Tadao Nagatsuma (Eds.): Handbook o...
- Analytical applications of MIPs in diagnostic assa...
- Resveratrol Protects PC12 Cell against 6-OHDA Dama...
- Haemodynamic Effects of Lung Recruitment Manoeuvres
- Study on the Difference of BIS/BAS Scale between S...
- The Effect of Dimethyl Sulfoxide on Supercoiled DN...
- Assessment of influenza vaccine effectiveness in a...
- Neutralizing antibody and functional mapping of Ba...
- Arguments and sources on Italian online forums on ...
- Annual influenza vaccination reduces total hospita...
- Estimation of parameters related to vaccine effica...
- Rotavirus – Global research density equalizing map...
- Toxicity assessment of Clostridium difficile toxin...
- Serotypes, antimicrobial susceptibility, and molec...
- An approach to death as an adverse event following...
-
▼
Νοε 22
(68)
Αναζήτηση αυτού του ιστολογίου
Κυριακή 22 Νοεμβρίου 2015
Transfusion strategy in hematological intensive care unit: study protocol for a randomized controlled trial
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.