Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin

Publication date: Available online 30 October 2015
Source:Bioorganic & Medicinal Chemistry
Author(s): Benjamin P. Martin, Elena Vasilieva, Cynthia M. Dupureur, Christopher D. Spilling
New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. Surprisingly, the phosphate, phosphonate, and difluorophosphonate analogs all showed diminished activity when compared with the natural product.

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