MicroRNA-498 Inhibition Enhances the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells into Podocyte-Like Cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1OShHwT via IFTTT
Towards molecular mechanisms regulating the expression of galectins in cancer cells under microenvironmental stress conditions
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Galectins, a family of soluble β-galactoside-binding proteins, serve as mediators of fundamental biological processes, such as cell growth, differentiation, adhesion, migration, survival, and death. The purpose of this review is to summarize the current knowledge regarding the ways in which the expression of individual galectins differs in normal and transformed human cells exposed to various stimuli mimicking physiological and pathological microenvironmental stress conditions. A conceptual point is being made and grounded that the modulation of galectin expression profil... περισσότερα »
Tubulin acetylation: responsible enzymes, biological functions and human diseases
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Microtubules have important functions ranging from maintenance of cell morphology to subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the organismal level, microtubules are crucial for various biological processes, such as viral entry, inflammation, immunity, learning and memory in mammals. Microtubules are subject to various covalent modifications. One such modification is tubulin acetylation, which is associated with stable microtubules and conserved from protists to humans. In the past three decades, this reversible modifica... περισσότερα »
PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Oncogenic mutants of c-Kit are often found in mastocytosis, gastrointestinal stromal tumors and acute myeloid leukemia. The activation mechanism of the most commonly occurring mutation, D816V in exon 17 of c-Kit, has been well-studied while other mutations remain fairly uncharacterized in this respect. In this study, we show that the constitutive activity of the exon 11 mutant V560D is weaker than the D816V mutant. Phosphorylation of downstream signaling proteins induced by the ligand for c-Kit, stem cell factor, was stronger in c-Kit/V560D expressing cells than in cells ... περισσότερα »
Two independently folding units of Plasmodium profilin suggest evolution via gene fusion
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Gene fusion is a common mechanism of protein evolution that has mainly been discussed in the context of multidomain or symmetric proteins. Less is known about fusion of ancestral genes to produce small single-domain proteins. Here, we show with a domain-swapped mutant *Plasmodium* profilin that this small, globular, apparently single-domain protein consists of two foldons. The separation of binding sites for different protein ligands in the two halves suggests evolution via an ancient gene fusion event, analogous to the formation of multidomain proteins. Finally, the two ...περισσότερα »
The immune response to cytomegalovirus in allogeneic hematopoietic stem cell transplant recipients
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Approximately, up to 70 % of the human population is infected with cytomegalovirus (CMV) that persists for life in a latent state. In healthy people, CMV reactivation induces the expansion of CMV-specific T cells up to 10 % of the entire T cell repertoire. On the contrary, CMV infection is a major opportunistic viral pathogen that remains a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Due to the delayed CMV-specific immune recovery, the incidence of CMV reactivation during post-transplant period is very high. Several m... περισσότερα »
Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Protein homeostasis is fundamental for cell function and survival, because proteins are involved in all aspects of cellular function, ranging from cell metabolism and cell division to the cell's response to environmental challenges. Protein homeostasis is tightly regulated by the synthesis, folding, trafficking and clearance of proteins, all of which act in an orchestrated manner to ensure proteome stability. The protein quality control system is enhanced by stress response pathways, which take action whenever the proteome is challenged by environmental or physiological s... περισσότερα »
Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Changes in nucleolar morphology and function are tightly associated with cellular activity, such as growth, proliferation, and cell cycle progression. Historically, these relationships have been extensively examined in cancer cells, which frequently exhibit large nucleoli and increased ribosome biogenesis. Recent findings indicate that alteration of nucleolar activity is a key regulator of development and aging. In this review, we have provided evidences that the nucleolus is not just a housekeeping factor but is actively involved in the regulation of cell proliferation, ... περισσότερα »
Initiation of mRNA translation in bacteria: structural and dynamic aspects
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Initiation of mRNA translation is a major checkpoint for regulating level and fidelity of protein synthesis. Being rate limiting in protein synthesis, translation initiation also represents the target of many post-transcriptional mechanisms regulating gene expression. The process begins with the formation of an unstable 30S pre-initiation complex (30S pre-*IC*) containing initiation factors (IFs) IF1, IF2 and IF3, the translation initiation region of an mRNA and initiator fMet-tRNA whose codon and anticodon pair in the P-site following a first-order rearrangement of the 3... περισσότερα »
Fast-folding proteins under stress
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Proteins are subject to a variety of stresses in biological organisms, including pressure and temperature, which are the easiest stresses to simulate by molecular dynamics. We discuss the effect of pressure and thermal stress on very-fast-folding model proteins, whose in vitro folding can be fully simulated on computers and compared with experiments. We then discuss experiments that can be used to subject proteins to low- and high-temperature unfolding, as well as low- and high-pressure unfolding. Pressure and temperature are prototypical perturbations that illustrate how ... περισσότερα »
Routine check for plagiarism
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
from Cell via ola Kala on Inoreader http://ift.tt/1R9rpZq via IFTTT
Bidirectional actin transport is influenced by microtubule and actin stability
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Local and long-distance transport of cytoskeletal proteins is vital to neuronal maintenance and growth. Though recent progress has provided insight into the movement of microtubules and neurofilaments, mechanisms underlying the movement of actin remain elusive, in large part due to rapid transitions between its filament states and its diverse cellular localization and function. In this work, we integrated live imaging of rat sensory neurons, image processing, multiple regression analysis, and mathematical modeling to perform the first quantitative, high-resolution investi... περισσότερα »
Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract The establishment of neuronal polarity and axonal outgrowth are key processes affecting neuronal migration and synapse formation, their impairment likely leading to cognitive deficits. Here we have found that the apoptotic protease activating factor 1 (Apaf1), apart from its canonical role in apoptosis, plays an additional function in cortical neurons, where its deficiency specifically impairs axonal growth. Given the central role played by centrosomes and microtubules in the polarized extension of the axon, our data suggest that Apaf1-deletion affects axonal outgrowth th... περισσότερα »
Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Telomeres are protective heterochromatic structures that cap the end of linear chromosomes and play a key role in preserving genomic stability. Telomere length represents a balance between processes that shorten telomeres during cell divisions with incomplete DNA replication and the ones that lengthen telomeres by the action of telomerase, an RNA–protein complex with reverse transcriptase activity which adds telomeric repeats to DNA molecule ends. Telomerase activity and telomere length have a crucial role in cellular ageing and in the pathobiology of several human disease... περισσότερα »
Identification and functional analysis of olfactory receptor family reveal unusual characteristics of the olfactory system in the migratory locust
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Locusts represent the excellent model of insect olfaction because the animals are equipped with an unusual olfactory system and display remarkable density-dependent olfactory plasticity. However, information regarding receptor molecules involved in the olfactory perception of locusts is very limited. On the basis of genome sequence and antennal transcriptome of the migratory locust, we conduct the identification and functional analysis of two olfactory receptor families: odorant receptors (ORs) and ionotropic receptors (IRs). In the migratory locust, there is an expansion... περισσότερα »
Epigenetic regulation of the intestinal epithelium
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract The intestinal epithelium is an ideal model system for the study of normal and pathological differentiation processes. The mammalian intestinal epithelium is a single cell layer comprising proliferative crypts and differentiated villi. The crypts contain both proliferating and quiescent stem cell populations that self-renew and produce all the differentiated cell types, which are replaced every 3–5 days. The genetics of intestinal development, homeostasis, and disease are well defined, but less is known about the contribution of epigenetics in modulating these processes. ... περισσότερα »
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the development of a large part of the mouse brain over 25 years ago. We have since learned that Wnt family secreted glycolipoproteins, of which there are nineteen, which activate a diverse network of signals that are particularly important during embryonic development and tissue regeneration. Wnt signals in the developing and adult brain can drive neural stem cell self-renewal, expansion, asymmetric cell division, maturation and differentiation. The molecular events taking place after a Wnt bi... περισσότερα »
Regulation of αA- and αB-crystallins via phosphorylation in cellular homeostasis
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract αA-Crystallin (αA) and αB-crystallin (αB) are small heat shock proteins responsible for the maintenance of transparency in the lens. In non-lenticular tissues, αB is involved in both maintenance of the cytoskeleton and suppression of neurodegeneration amongst other roles. Despite their importance in maintaining cellular health, modifications and mutations to αA and αB appear to play a role in disease states such as cataract and myopathies. The list of modifications that have been reported is extensive and include oxidation, disulphide bond formation, C- and N-terminal tru... περισσότερα »
Complexins: small but capable
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Despite intensive research, it is still unclear how an immediate and profound acceleration of exocytosis is triggered by appropriate Ca2+-stimuli in presynaptic terminals. This is due to the fact that the molecular mechanisms of "docking" and "priming" reactions, which set up secretory vesicles to fuse at millisecond time scale, are extremely hard to study. Yet, driven by a fruitful combination of in vitro and in vivo analyses, our mechanistic understanding of Ca2+-triggered vesicle fusion has certainly advanced in the past few years. In this review, we aim to highlight re... περισσότερα »
Human dendritic cell subsets and function in health and disease
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract The method of choice for the development of new vaccines is to target distinct dendritic cell subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated immunity or induce tolerance to specific antigens. The innate functions of dendritic cells themselves may also be targeted by inhibitors or activators that would target a specific function such as interferon production, potentially important in autoimmune disease and chronic viral infections. Importantly targeting dendritic cells requires detailed knowledge of both the surface phenotype and... περισσότερα »
Mirror movements after stroke suggest facilitation from non primary motor cortex: a case report
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
When stroke occurs in adulthood, mirror movements (MMs: involuntary movements occurring in one hand when performing unilateral movements with the contralateral hand) in the paretic hand rarely occur. We present a case of an apparently healthy 54-year-old male presenting MMs in his left (non-dominant) hand. Further evaluation revealed diminished strength and dexterity in left hand, increased spinal excitability, decreased corticospinal excitability, occurrence of ipsilateral motor responses, enlarged cortical motor representation and imaging findings consistent with a previously un... περισσότερα »
A Randomized Controlled Trial to Evaluate the Veterans’ In-home Program (VIP) for Military Veterans with Traumatic Brain Injury and their Families: Report on Impact for Family Members
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Traumatic brain injury (TBI) creates many challenges for families as well as patients. Few intervention studies have considered both the needs of the person with TBI and his family and included both in the intervention process. To address this gap, we designed an innovative intervention for veterans with TBI and families—the Veterans' In-home Program (VIP)—targeting veterans' environment, delivered in veterans' homes, and involving their families. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Raus3B via IFTTT
Functional outcomes and unplanned transfers of pediatric patients with central neurological impairments receiving inpatient rehabilitation care with cancer and non-cancer diagnoses
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Functional impairments from central nervous system (CNS) dysfunction experienced by pediatric patients with cancer diagnoses are well documented. However, little is known of these patients' functional outcomes and potential complications while receiving inpatient rehabilitation services. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1LYCBrx via IFTTT
Objective Sedentary Time, MVPA, and Physical Capability in a British Cohort.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Purpose: Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time with physical functional health independent of time spent in moderate-vigorous physical activity (MVPA). Methods: Community-based men and women (n=8623, 48-92 years old) in the European Prospective Investigation of Cancer-Norfolk study attended a health examination for objective measurement of physical capability, including grip strength (Smedley dynamometer, kg), usual walking speed (UWS, cm/s) and timed chair stands speed (TCSS... περισσότερα »
Physical Activity, Television Viewing Time and 12-Year Changes in Waist Circumference.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Purpose: Both moderate-to-vigorous physical activity (MVPA) and sedentary behavior can be associated with adult adiposity. Much of the relevant evidence is from cross-sectional studies or from prospective studies with relevant exposure measures at a single time point prior to weight gain or incident obesity. This study examined whether changes in MVPA and television (TV) viewing time are associated with subsequent changes in waist circumference, using data from three separate observation points in a large population-based prospective study of Australian adults. Methods: Data were ob... περισσότερα »
Partial weight support of the arm affects corticomotor selectivity of biceps brachii
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Background: Weight support of the arm (WS) can be used in stroke rehabilitation to facilitate upper limb therapy, but the neurophysiological effects of this technique are not well understood. While an overall reduction in muscle activity is expected, the mechanism by which WS may alter the expression of muscle synergies has not been examined until now. We explored the neurophysiological effect of WS on the selectivity of biceps brachii (BB) activation in healthy adults. Methods: Thirteen participants completed counterbalanced movement tasks in a repeated measures design. Three lev...περισσότερα »
Transport of Nanoparticle-Stabilized CO $$_2$$ 2 -Foam in Porous Media
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Abstract Foam is injected in the subsurface to improve mobility control through the increase in the effective gas viscosity, e.g., in CO \(_2\) -based enhanced oil recovery processes. As fine-textured foam has higher viscosity, it is envisaged to achieve an optimal foam texture and to maintain it for the entire period of an application. However, mechanisms of foam formation and destruction, which affect texture, are difficult to regulate. In this study, we investigate the synergic effect of nanoparticles and surfactant on the foam texture and the effective gas viscosity ( \(\mu _g^... περισσότερα »
The Military Acute Concussion Evaluation (MACE) is time sensitive.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GEHSUQ via IFTTT
Re: Utility of the Military Acute Concussion Evaluation as a screening tool for mild traumatic brain injury in a civilian trauma population.
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1KBw9Br via IFTTT
Upper-limb deep vein thrombosis in Paget-Schroetter syndrome
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
A 43-YEAR-OLD MAN with no medical history presented with pain and swelling in his left arm for 2 weeks. He was a regular weight lifter, and his exercise routine included repetitive hyperextension and... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PRlG9L via IFTTT
A 56-year-old with diarrhea and weakness
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
A 56-YEAR-OLD MAN presents to the emergency department with nausea, weakness, and exertional dyspnea, which have been going on for 1 week. He is sent by his primary care physician after being noted... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1LVH92g via IFTTT
Middle East respiratory syndrome: SARS redux?
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
MIDDLE EAST RESPIRATORY SYNDROME (MERS) is a potentially lethal illness caused by the Middle East respiratory syndrome coronavirus (MERS-CoV). The virus was first reported in 2012, when it was... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ORUkDy via IFTTT
Respiratory artifact: A second vital sign on the electrocardiogram
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
A 57-YEAR-OLD MAN hospitalized for treatment of multilobar pneumonia was noted to have a rapid, irregular heart rate on telemetry. He was hypoxemic and appeared to be in respiratory distress. A... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1i9SWxz via IFTTT
Parvovirus mimicking acute HIV infection
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
A 25-YEAR-OLD JAMAICAN MAN presented to the emergency department for evaluation of a rash on his face, back, and hands (*Figure 1*). He recalled a puncture injury after handling garbage at work.... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ORUmet via IFTTT
Electrocardiographic changes in amitriptyline overdose
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
A 49-YEAR-OLD WOMAN with a history of depression, bipolar disorder, and chronic back pain was brought to the emergency department unresponsive after having taken an unknown quantity of amitriptyline... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1i9STBY via IFTTT
ST-segment elevation: Differential diagnosis, caveats
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
WHEN THE ST SEGMENT is elevated on the electrocardiogram, our first concern is whether the patient is having an ST-segment elevation myocardial infarction (STEMI). However, a number of other... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GtmkdZ via IFTTT
Corneal opacities in a man with chronic kidney disease
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
A 40-YEAR-OLD MAN with end-stage renal disease on intermittent hemodialysis presented to the emergency department with a 1-week history of pain affecting his left lower back, left flank, and left... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1i9SS0S via IFTTT
To the Editor: Enterovirus D-68 presenting with acute pancreatitis
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
*TO THE EDITOR:* We read the review on enterovirus D681 (EV-D68) with great interest, and we thought it merited comment. During the current influenza season, we have had several... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Gtml1v via IFTTT
To the Editor: Alcoholic hepatitis: An important consideration
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
*TO THE EDITOR:* I read with keen interest the high-quality review of the pathogenesis, diagnosis, and management of alcoholic hepatitis by <link... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1i9SRdj via IFTTT
Lactic acidosis: Clinical implications and management strategies
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
PHYSICIANS ARE PAYING MORE ATTENTION to serum lactate levels in hospitalized patients than in the past, especially with the advent of point-of-care testing. Elevated lactate levels are associated... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GtmkuB via IFTTT
ST-segment elevation: Differential diagnosis, caveats
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
WHEN THE ST SEGMENT is elevated on the electrocardiogram, our first concern is whether the patient is having an ST-segment elevation myocardial infarction (STEMI). However, a number of other... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GtmkdZ via IFTTT
Alcoholic hepatitis: Challenges in diagnosis and management
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
ALCOHOLIC HEPATITIS, a severe manifestation of alcoholic liver disease, is rising in incidence. Complete abstinence from alcohol remains the cornerstone of treatment, while other specific... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GtmjXy via IFTTT
The Surviving Sepsis Campaign: Where have we been and where are we going?
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
SEPSIS IS FAMILIAR to most physicians in clinical practice, but guidance from the medical literature on how best to manage it has traditionally been confusing. Starting in 2002, the Surviving... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1i9SO19 via IFTTT
Ebola—lessons still to be learned
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
In this issue of the Journal, <link... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GtmhyT via IFTTT
Ebola virus: Questions, answers, and more questions
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
*A 50-year-old man who returned from a business trip to Nigeria 24 days ago presents with complaints of the sudden onset of fever, diarrhea, myalgia, and headache. He reports 10 bowel movements per...* from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GtmiTk via IFTTT
Does massive hemoptysis always merit diagnostic bronchoscopy?
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
Yes, all patients with massive hemoptysis should undergo diagnostic bronchoscopy. The procedure plays an important role in protecting the airway, maintaining ventilation, finding the site and... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1i9SMpP via IFTTT
Acute respiratory distress syndrome: Implications of recent studies
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
Continued progress in understanding the pathophysiology of acute respiratory distress syndrome (ARDS) is translating into changes in the way we diagnose... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1i9SM9i via IFTTT
Double trouble: Simultaneous complications of therapeutic thoracentesis
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
A 51-year-old man with end-stage liver disease from alcohol abuse presented with worsening dyspnea on exertion. He had a history of ascites requiring... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1i9SK1q via IFTTT
Changes to practice may help avoid ‘double trouble’
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
Large-volume thoracentesis is defined as the drainage of more than 1 L of fluid. Inherent in this procedure is the removal of a large amount of fluid... from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1GtmeTE via IFTTT
Traumatic brain injury in Africa in 2050: a modeling study
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
European Journal of Neurology
Trauma center variation in the management of pediatric patients with blunt abdominal solid organ injury: a national trauma data bank analysis
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
Journal of Pediatric Surgery
Dirofilariasis Mimicking an Acute Scrotum
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 λεπτό
Pediatric Emergency Care
Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update.
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 4 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] Related Articles *Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update.* Arch Pathol Lab Med. 2015 Oct;139(10):1211-4 Authors: Harmon CM, Brown N Abstract Langerhans cell histiocytosis (LCH) comprises a wide spectrum of clinical disorders that have in common a proliferation of Langerhans-type cells with characteristic morphologic, immunophenotypic, and ultrastructural features. In part because of the diverse clinical manifestations of LCH, there has long been controversy over whether LCH is b...περισσότερα »
Reed-Sternberg-Like Cells in Non-Hodgkin Lymphomas.
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 4 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] Related Articles *Reed-Sternberg-Like Cells in Non-Hodgkin Lymphomas.* Arch Pathol Lab Med. 2015 Oct;139(10):1205-10 Authors: Gomez-Gelvez JC, Smith LB Abstract Large atypical cells with morphologic and immunophenotypic features resembling Reed-Sternberg cells can be seen in the background of reactive lymphadenopathies as well as non-Hodgkin lymphomas. The presence of these cells is an important diagnostic pitfall that must be recognized by pathologists who regularly interpret lymph node biopsies. A thorough evaluation of the morp... περισσότερα »
Molecular analysis of type II topoisomerases of Aeromonas hydrophila isolated from fish and levofloxacin-induced resistant isolates in vitro
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 5 δευτερόλεπτα
Abstract The mechanisms of resistance to levofloxacin for *Aeromonas hydrophila* isolated from diseased fish and selected in vitro were examined in this study. Levofloxacin-resistant mutants were obtained by selection of *A. hydrophila* in vitro. The quinolone resistance-determining regions (QRDRs) of the *gyrA* and *parC* genes were sequenced in LevR strains and reverse mutation strains. All LevR strains carried a point mutation at codon 83 (Ser → Ile), and one strain (25 %) harbored a mutation at position 92 (Leu → Met) in the GyrA-QRDR. After being transferred in a levofloxacin-... περισσότερα »
Rationale design of quorum-quenching peptides that target the VirSR system of Clostridium perfringens
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 5 δευτερόλεπτα
In *Clostridium perfringens*, a 5-membered thiolactone peptide acts as an autoinducing peptide (AIPCp) to activate the VirSR two-component signal transduction system, which in turn controls the expression of genes encoding multiple toxins, including α, and . To develop anti-pathogenic agents against virulent *C. perfringens*, quorum-quenching peptides were rationally designed based on the structure–activity relationship (SAR) data on AIPCp. Alanine scanning study of AIPCp suggested that Trp3 and Phe4 are involved in receptor binding and activation, respectively. On the basis of th... περισσότερα »
Genetic analysis of environmental strains of the plant pathogen Phytophthora capsici reveals heterogeneous repertoire of effectors and possible effector evolution via genomic island
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 5 δευτερόλεπτα
*Phytophthora capsici* is a virulent oomycete pathogen of many vegetable crops. Recently, it has been demonstrated that the recognition of the RXLR effector AVR3a1 of *P. capsici* (PcAVR3a1) triggers a hypersensitive response and plays a critical role in mediating non-host resistance. Here, we analyzed the occurrence of PcAVR3a1 in 57 isolates of *P. capsici* derived from globe squash, eggplant, tomato and bell pepper cocultivated in a small geographical area. The occurrence of PcAVR3a1 in environmental strains of *P. capsici* was confirmed by PCR in only 21 of these pathogen isol... περισσότερα »
Revisiting bacterial cyclic nucleotide phosphodiesterases: cyclic AMP hydrolysis and beyond
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 5 δευτερόλεπτα
Cyclic-3',5'-adenosine monophosphate (cAMP) is a universal second messenger that regulates vital activities in bacteria and eukaryotes. Enzymes that hydrolyze cAMP, called phosphodiesterases (PDEs), negatively regulate the levels of this messenger molecule and are therefore crucial for signal 'termination'. In this minireview, I shall summarize the available literature on bacterial cAMP-PDEs, with particular emphasis on enzymes belonging to the ubiquitously encoded Class III PDE family exemplified by CpdA from *Escherichia coli* and Rv0805 from *Mycobacterium tuberculosis*. Using ...περισσότερα »
Rationale design of quorum-quenching peptides that target the VirSR system of Clostridium perfringens
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 5 δευτερόλεπτα
In *Clostridium perfringens*, a 5-membered thiolactone peptide acts as an autoinducing peptide (AIPCp) to activate the VirSR two-component signal transduction system, which in turn controls the expression of genes encoding multiple toxins, including α, and . To develop anti-pathogenic agents against virulent *C. perfringens*, quorum-quenching peptides were rationally designed based on the structure–activity relationship (SAR) data on AIPCp. Alanine scanning study of AIPCp suggested that Trp3 and Phe4 are involved in receptor binding and activation, respectively. On the basis of th... περισσότερα »
Production of autoinducer-2 by aerobic endospore-forming bacteria isolated from the West African fermented foods
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 5 δευτερόλεπτα
Autoinducer-2 (AI-2) is a quorum-sensing (QS) molecule which mediates interspecies signaling and affects various bacterial behaviors in food fermentation. Biosynthesis of AI-2 is controlled by S-ribosylhomocysteine lyase encoded by the *luxS* gene. The objective of this study was to investigate production of AI-2 by aerobic endospore-forming bacteria (AEB) isolated from the West African alkaline fermented seed products *Mantchoua* and *Maari*. The study included 13 AEB strains of *Bacillus subtilis*, *B. cereus*, *B. altitudinis*, *B. amyloliquefaciens*, *B. licheniformis*, *B. ar... περισσότερα »
Photodermatology and Photomedicine: Meeting Calendar
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 5 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1Wfatlx via IFTTT
Editor's Picks
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 5 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1N48yQ1 via IFTTT
Auditory Training
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
How Does Auditory Training Work? Joined-Up Thinking and Listening by Ferguson, Melanie via Hearing Semin Hear 2015; 36: 237-249 DOI: 10.1055/s-0035-1564456 Auditory training aims to compensate for degradation in the auditory signal and is offered as an intervention to help alleviate the most common complaint in people with hearing loss, understanding speech in a background noise. Yet there remain many unanswered questions. This article reviews some of the key pieces of evidence that assess the evidence for whether, and how, auditory training benefits adults with hearing loss. The evide... περισσότερα »
Central Auditory Processing Disorder Service
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Results from a National Central Auditory Processing Disorder Service: A Real-World Assessment of Diagnostic Practices and Remediation for Central Auditory Processing Disorder by Cameron, Sharon via Hearing Semin Hear 2015; 36: 216-236 DOI: 10.1055/s-0035-1564457 This article describes the development and evaluation of a national service to diagnose and remediate central auditory processing disorder (CAPD). Data were gathered from 38 participating Australian Hearing centers over an 18-month period from 666 individuals age 6, 0 (years, months) to 24, 8 (median 9, 0). A total of 408 clie...περισσότερα »
Meaning-Based Auditory Training
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
The Effects of Meaning-Based Auditory Training on Behavioral Measures of Perceptual Effort in Individuals with Impaired Hearing by Sommers, Mitchell S. via Hearing Semin Hear 2015; 36: 263-272 DOI: 10.1055/s-0035-1564454 There has been considerable interest in measuring the perceptual effort required to understand speech, as well as to identify factors that might reduce such effort. In the current study, we investigated whether, in addition to improving speech intelligibility, auditory training also could reduce perceptual or listening effort. Perceptual effort was assessed using a mo... περισσότερα »
Auditory Training for Central Auditory Processing Disorder
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Auditory Training for Central Auditory Processing Disorder by Weihing, Jeffrey via Hearing Semin Hear 2015; 36: 199-215 DOI: 10.1055/s-0035-1564458 Auditory training (AT) is an important component of rehabilitation for patients with central auditory processing disorder (CAPD). The present article identifies and describes aspects of AT as they relate to applications in this population. A description of the types of auditory processes along with information on relevant AT protocols that can be used to address these specific deficits is included. Characteristics and principles of effecti...περισσότερα »
Auditory Training for Adults with Hearing Loss
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Options for by Olson, Anne D. via Hearing Semin Hear 2015; 36: 284-295 DOI: 10.1055/s-0035-1564461 Hearing aid devices alone do not adequately compensate for sensory losses despite significant technological advances in digital technology. Overall use rates of amplification among adults with hearing loss remain low, and overall satisfaction and performance in noise can be improved. Although improved technology may partially address some listening problems, auditory training may be another alternative to improve speech recognition in noise and satisfaction with devices. The literature ... περισσότερα »
Seminars in Hearing
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 15 δευτερόλεπτα
- Self-Assessment Questions2015-10-27 10:01:25 AM Semin Hear 2015; 36: C1-C10 DOI: 10.1055/s-0035-1564462 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Full text Read moreTop - Auditory Training for Central Auditory Processing DisorderWeihing, Jeffrey, 2015-10-27 10:01:25 AM Semin Hear 2015; 36: 199-215 DOI: 10.1055/s-0035-1564458 Auditory training (AT) is an important component of rehabilitation for patients with central auditory processing disorder (CAPD). The present... περισσότερα »
Journal of Plastic, Reconstructive & Aesthetic Surgery
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 16 δευτερόλεπτα
- The Kinect Recording System for Objective Three- and Four-Dimensional Breast Assessment with Image OverlaysHenseler Helga, Bonkat Sarah Kim, Vogt Peter, Rosenhahn Bodo, 2015-10-27 09:19:20 AM We investigated the application of the validated portable Kinect camera for three-and fourdimensional breast assessment in female life models. Read moreTop - Serum Levels of Renin, Angiotensin Converting Enzyme and Angiotensin II in Patients Treated by Surgical Excision, Propranolol and Captopril for Problematic Proliferating Infantile HaemangiomaL. Sulzberger, R. ... περισσότερα »
How Does Auditory Training Work? Joined-Up Thinking and Listening
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
Semin Hear 2015; 36: 237-249 DOI: 10.1055/s-0035-1564456 Auditory training aims to compensate for degradation in the auditory signal and is offered as an intervention to help alleviate the most common complaint in people with hearing loss, understanding speech in a background noise. Yet there remain many unanswered questions. This article reviews some of the key pieces of evidence that assess the evidence for whether, and how, auditory training benefits adults with hearing loss. The evidence supports that improvements occur on the trained task; however, transfer of that learning t... περισσότερα »
Evaluation of Speech-Perception Training for Hearing Aid Users: A Multisite Study in Progress
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
Semin Hear 2015; 36: 273-283 DOI: 10.1055/s-0035-1564453 Following an overview of theoretical issues in speech-perception training and of previous efforts to enhance hearing aid use through training, a multisite study, designed to evaluate the efficacy of two types of computerized speech-perception training for adults who use hearing aids, is described. One training method focuses on the identification of 109 syllable constituents (45 onsets, 28 nuclei, and 36 codas) in quiet and in noise, and on the perception of words in sentences presented in various levels of noise. In a secon... περισσότερα »
Electrophysiologic Assessment of Auditory Training Benefits in Older Adults
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
Semin Hear 2015; 36: 250-262 DOI: 10.1055/s-0035-1564455 Older adults often exhibit speech perception deficits in difficult listening environments. At present, hearing aids or cochlear implants are the main options for therapeutic remediation; however, they only address audibility and do not compensate for central processing changes that may accompany aging and hearing loss or declines in cognitive function. It is unknown whether long-term hearing aid or cochlear implant use can restore changes in central encoding of temporal and spectral components of speech or improve cognitive ... περισσότερα »
Self-Assessment Questions
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
Semin Hear 2015; 36: C1-C10 DOI: 10.1055/s-0035-1564462 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Full text from Audiology via ola Kala on Inoreader http://ift.tt/1ibqDio via IFTTT Semin Hear 2015; 36: C1-C10 DOI: 10.1055/s-0035-1564462 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Full text
Optimizing Performance in Adult Cochlear Implant Users through Clinician Directed Auditory Training
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
Semin Hear 2015; 36: 296-310 DOI: 10.1055/s-0035-1564460 Clinician-directed auditory training using the KTH Speech Tracking Procedure can be a powerful approach for maximizing outcomes with adult cochlear implant (CI) users. This article first reviews prior research findings from an 8-week clinician-directed auditory training (AT) program using speech tracking that yielded significant gains in speech tracking rate and sentence recognition scores following training. The second focus of the article is to illustrate the value of intensive face-to-face long-term AT using speech tracki... περισσότερα »
Asymmetric Hearing Loss in Chinese Workers Exposed to Complex Noise.
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
Objectives: Evaluate the audiometric asymmetry in Chinese industrial workers and investigate the effects of noise exposure, sex, and binaural average thresholds on audiometric asymmetry. Design: Data collected from Chinese industrial workers during a cross-sectional study were reanalyzed. Of the 1388 workers, 266 met the inclusion criteria for this study. Each subject underwent a physical examination and an otologic examination and completed a health-related questionnaire. [chi]2 and t tests were used to examine the differences between the asymmetric and symmetric hearing loss group...περισσότερα »
Speech Perception With Combined Electric-Acoustic Stimulation: A Simulation and Model Comparison
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
[image: image]Objective: The aim of this study is to simulate speech perception with combined electric-acoustic stimulation (EAS), verify the advantage of combined stimulation in normal-hearing (NH) subjects, and then compare it with cochlear implant (CI) and EAS user results from the authors' previous study. Furthermore, an automatic speech recognition (ASR) system was built to examine the impact of low-frequency information and is proposed as an applied model to study different hypotheses of the combined-stimulation advantage. Signal-detection-theory (SDT) models were applied to a... περισσότερα »
Short-Term and Working Memory Impairments in Early-Implanted, Long-Term Cochlear Implant Users Are Independent of Audibility and Speech Production
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
[image: image]Objective: To determine whether early-implanted, long-term cochlear implant (CI) users display delays in verbal short-term and working memory capacity when processes related to audibility and speech production are eliminated. Design: Twenty-three long-term CI users and 23 normal-hearing controls each completed forward and backward digit span tasks under testing conditions that differed in presentation modality (auditory or visual) and response output (spoken recall or manual pointing). Results: Normal-hearing controls reproduced more lists of digits than the CI users, ... περισσότερα »
Evaluation of Speech-Evoked Envelope Following Responses as an Objective Aided Outcome Measure: Effect of Stimulus Level, Bandwidth, and Amplification in Adults With Hearing Loss
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
[image: image]Objectives: The present study evaluated a novel test paradigm based on speech-evoked envelope following responses (EFRs) as an objective aided outcome measure for individuals fitted with hearing aids. Although intended for use in infants with hearing loss, this study evaluated the paradigm in adults with hearing loss, as a precursor to further evaluation in infants. The test stimulus was a naturally male-spoken token /susa∫i/, modified to enable recording of eight individual EFRs, two from each vowel for different formants and one from each fricative. In experiment I, ... περισσότερα »
Effects of Aging on the Encoding of Dynamic and Static Components of Speech
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
[image: image]Objectives: The authors investigated aging effects on the envelope of the frequency following response to dynamic and static components of speech. Older adults frequently experience problems understanding speech, despite having clinically normal hearing. Improving audibility with hearing aids provides variable benefit, as amplification cannot restore the temporal precision degraded by aging. Previous studies have demonstrated age-related delays in subcortical timing specific to the dynamic, transition region of the stimulus. However, it is unknown whether this delay is... περισσότερα »
Nasal Mucociliary Clearance
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
in Adenoid Hypertrophy and Otitis Media with Effusion via Current Allergy and Asthma Reports AbstractMucociliary clearance (MCC), which exists in many systems, is the first defensive mechanism of the human body. Nasal MCC has an important role in transporting the secretions of the nasal cavity and paranasal sinuses along with the trapped inhaled pathogens to the nasopharynx. Physiologic or pathologic situations that effect nasal MCC, such as temperature, humidity, nasal obstruction, allergic rhinitis, chronic infections, etc., lead to impaired MCC and related local or circumjacent s...περισσότερα »
Current Allergy and Asthma Reports
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 19 δευτερόλεπτα
- Laboratory Animal Allergy in the Modern Era2015-10-26 02:00:00 AM Abstract Laboratory animal workers face a high risk of developing laboratory animal allergy as a consequence of inhaling animal proteins at work; this has serious consequences for their health and future employment. Exposure to animal allergen remains to be the greatest risk factor although the relationship is complex, with attenuation at high allergen exposure. Recent evidence suggests that this may be due to a form of natural immunotolerance. Furthermore, the pattern of exposure to aller... περισσότερα »
Animal Allergy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Laboratory Animal Allergy in the Modern Era via Current Allergy and Asthma Reports AbstractLaboratory animal workers face a high risk of developing laboratory animal allergy as a consequence of inhaling animal proteins at work; this has serious consequences for their health and future employment. Exposure to animal allergen remains to be the greatest risk factor although the relationship is complex, with attenuation at high allergen exposure. Recent evidence suggests that this may be due to a form of natural immunotolerance. Furthermore, the pattern of exposure to allergen may also b...περισσότερα »
Cutaneous Vasculitis Associated With Levamisole-Adulterated Cocaine
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] *Levamisole-Induced Vasculitis: A Characteristic Cutaneous Vasculitis Associated With Levamisole-Adulterated Cocaine.* Arch Pathol Lab Med. 2015 ;139(8):1058-61 Authors: Roberts JA, Chévez-Barrios P Abstract Levamisole-induced vasculitis is a characteristic cutaneous vasculitis syndrome associated with the use of levamisole-adulterated cocaine. Patients will typically present with a painful, purpuric rash in a retiform or stellate pattern with or without central necrosis involving the extremities, trunk, nasal tip, digits, cheeks, and/o... περισσότερα »
Thyroid Paraganglioma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] *.* Arch Pathol Lab Med. 2015 ; Authors: Lee SM, Policarpio-Nicolas ML Abstract Thyroid paragangliomas are rare tumors that arise from the inferior laryngeal paraganglia. Most patients are female and present with an asymptomatic thyroid nodule. Histologically, the tumor is composed of cells arranged in a well-defined nest (zellballen) pattern surrounded by a thin fibrovascular stroma. It is a diagnostic pitfall and is occasionally misdiagnosed as follicular neoplasm, medullary thyroid carcinoma, intrathyroid parathyroid proliferation, ... περισσότερα »
Sclerosing Thymoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] Arch Pathol Lab Med. 2015;139(8):1068-70 Authors: Chatterjee D, Finch CJ Abstract Sclerosing thymoma is an extremely rare entity described mostly in the recent past and, to our knowledge, described in only 14 cases, including one we recently diagnosed at our institution. The pathogenesis and biologic behavior of this relatively unknown entity is still largely uncertain. However, there are several consistent findings among the cases described so far. It is mostly asymptomatic or patients may present with shortness of breath or chest pai... περισσότερα »
Transoral Robotic Surgery in Oropharyngeal Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] Arch Pathol Lab Med. 2015 ; Authors: Helman SN, Schwedhelm T, Kadakia S, Wang Y, Schiff BA, Smith RV Abstract Context .- The incidence of oropharyngeal squamous cell carcinoma has increased during the past decade and is related primarily to the human papillomavirus. This change in etiology, from tobacco and alcohol to human papillomavirus, has resulted in improved survival for the disease. In the United States, open resection had largely been replaced by concurrent chemotherapy and/or radiotherapy by the early 2000s. The advent of tra... περισσότερα »
Telemicrobiology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] *Review of Telemicrobiology.* Arch Pathol Lab Med. 2015 ; Authors: Rhoads DD, Mathison BA, Bishop HS, da Silva AJ, Pantanowitz L Abstract Context .- Microbiology laboratories are continually pursuing means to improve quality, rapidity, and efficiency of specimen analysis in the face of limited resources. One means by which to achieve these improvements is through the remote analysis of digital images. Telemicrobiology enables the remote interpretation of images of microbiology specimens. To date, the practice of clinical telemicrobiolog... περισσότερα »
Langerhans cell histiocytosis (LCH)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] *Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update.* Arch Pathol Lab Med. 2015 Oct;139(10):1211-4 Authors: Harmon CM, Brown N Abstract Langerhans cell histiocytosis (LCH) comprises a wide spectrum of clinical disorders that have in common a proliferation of Langerhans-type cells with characteristic morphologic, immunophenotypic, and ultrastructural features. In part because of the diverse clinical manifestations of LCH, there has long been controversy over whether LCH is best considered a reacti... περισσότερα »
Spitzoid melanocytic lesions
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
*Atypical Spitz Tumors: A Diagnostic Challenge.* Arch Pathol Lab Med. 2015 Oct;139(10):1263-70 Authors: Harms KL, Lowe L, Fullen DR, Harms PW [image: http:--allenpress.com-system-files-image] Abstract Spitzoid melanocytic lesions encompass a spectrum from benign Spitz nevi to malignant spitzoid melanomas. Spitzoid melanocytic neoplasms have significant morphologic and molecular differences from conventional melanocytic lesions, and prediction of biologic behavior and metastatic risk may be difficult. Most challenging is the atypical Spitz tumor, a borderline spitzoid melanocytic lesion...περισσότερα »
Immunohistochemistry: Carcinomas of Unknown Primary Site
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
[image: http:--allenpress.com-system-files-image] *Practical Applications in Immunohistochemistry: Carcinomas of Unknown Primary Site.* Arch Pathol Lab Med. 2015 Oct ; Authors: Kandalaft PL, Gown AM Abstract Context .- Identification of the site of origin of carcinoma of unknown primary using immunohistochemistry is a frequent requirement of anatomic pathologists. Diagnostic accuracy is crucial, particularly in the current era of targeted therapies and smaller sample sizes. Objectives .- To provide practical guidance and suggestions for classifying carcinoma of unknown primary using b... περισσότερα »
Identifying Thin Melanomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
and 20-Year Survival Rate Clinical Context Worldwide, the incidence of cutaneous melanoma continues to rise. The majority of patients have thin melanomas. Currently, the basic clinical features at presentation that tend to reduce a patient's chance of survival from primary melanoma are male sex; older age; and primary tumor site of the head, neck, trunk, palms, soles, or nail bed. Those with metastases in regional lymph nodes have the worst prognosis. The specific survival rates and determinants for the majority of patients (ie, those with thin melanomas) have been scarcely studied.... περισσότερα »
The ASCO Post, in partnership with the American Society of Clinical Oncology (ASCO), communicates news of the highest quality multidisciplinary cancer care to a broad audience of oncology professionals
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 36 δευτερόλεπτα
- Nivolumab Produces Survival Benefit in Advanced Renal Cell Carcinoma2015-10-27 09:38:33 AM Patients with advanced renal cell carcinoma treated with nivolumab (Opdivo) were 27% less likely to die than those receiving everolimus (Afinitor), in a planned interim analysis of the open-label phase III CheckMate 025 trial.1 These positive r Read moreTop - Expert Point of View: Cora N. Sternberg, MD, FACP2015-10-27 09:38:33 AM Cora N. Sternberg, MD, FACP, Chief of Medical Oncology at San Camillo Forlanini Hospital in Rome, Italy, formally discussed CheckMate 025 at th... περισσότερα »
Sentinel lymph node (SLN) biopsy,is not recommended for patients with melanomas that are ≤0.75 mm thick, according to guidelines from National Comprehensive Cancer Network (NCCN).
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
NCCN: Forgo Lymph Node Biopsy in Thin Melanomas HOLLYWOOD, Florida ― Sentinel lymph node (SLN) biopsy, the common staging procedure, is not recommended for patients with melanomas that are ≤0.75 mm thick, according to guidelines from National Comprehensive Cancer Network (NCCN). It is a rare ― and "very strong" ― bit of advice in the NCCN guidelines, said Daniel Coit, MD, of the Memorial Sloan Kettering Cancer Center (MSKCC), in New York City. "There aren't many places in any of the guidelines where we say, 'Not recommended,' " he told an audience here today at the National Comprehen... περισσότερα »
Thin Melanomas and New NICE Guidance for Sentinel Lymph Node Biopsy,LEVELS OF INVASION AND THICKNESS AS PROGNOSTIC MARKERS IN MELANOMA
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
*Thin Melanomas (<1mm)* *by J.A. Dunne, J. Odili, B.W.E.M. Powell via Plastic, Reconstructive & Aesthetic Surgery* *New melanoma diagnoses numbered 13,348 cases in 2011, with thin melanomas (Breslow thickness < 1mm) accounting for more than half.1,2 Recently published melanoma guidance from the National Institute for Health and Clinical Excellence (NICE) does not recommend sentinel lymph node biopsy (SLNB) for any melanoma ≤1mm Breslow thickness.1* *Article Citation:* *David E. Elder, (2011) Thin Melanoma. Archives of Pathology & Laboratory Medicine* *SPECIAL SECTION—UPDATE ON ME... περισσότερα »
The role of the renin-angiotensin system (RAS) in the biology of infantile haemangioma (IH) and its accelerated involution induced by β-blockers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Serum Levels of Renin, Angiotensin Converting Enzyme and Angiotensin II in Patients Treated by Surgical Excision, Propranolol and Captopril for Problematic Proliferating Infantile Haemangioma by L. Sulzberger, R. Baillie, T. Itinteang, S. de Jong, R. Marsh, P. Leadbitter, S.T. Tan via Plastic, Reconstructive & Aesthetic Surgery The role of the renin-angiotensin system (RAS) in the biology of infantile haemangioma (IH) and its accelerated involution induced by β-blockers was initially proposed in 2010. This led to the first clinical trial in 2012 using low-dose captopril, an angiotensi...περισσότερα »
DSPP Is Essential for Normal Development of the Dental-Craniofacial Complex
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 58 δευτερόλεπτα
The craniofacial skeleton is derived from both neural crest cells and mesodermal cells; however, the majority of the bone, cartilage, and connective tissue is derived from the neural crest. Dentin sialophosphoprotein (DSPP) is a precursor protein that is expressed by the connective tissues of the craniofacial skeleton, namely, bone and dentin with high expression levels in the dentin matrix. Gene ablation studies have shown severe dental defects in *DSPP*-null mutant mice. Therefore, to elucidate the role of *DSPP* on the developing dental-craniofacial complex, we evaluated phenot... περισσότερα »
Conditional TNF-{alpha} Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 58 δευτερόλεπτα
Tumor necrosis factor–α (TNF-α) is a proalgesic cytokine that is commonly expressed following tissue injury. TNF-α expression not only promotes inflammation but can also lead to pain hypersensitivity in nociceptors. With the established link between TNF-α and inflammatory pain, we identified its increased expression in the teeth of patients affected with caries and pulpitis. We generated a transgenic mouse model (TNF-αglo) that could be used to conditionally overexpress TNF-α. These mice were bred with a dentin matrix protein 1 (DMP1)–Cre line for overexpression of TNF-α in both t... περισσότερα »
A Study of the Association Between Sleep Bruxism, Low Quality of Sleep, and Degenerative Changes of the Temporomandibular Joint.
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 58 δευτερόλεπτα
The aim of this study was to evaluate the presence of degenerative bone changes of the temporomandibular joint (TMJ) in individuals suffering from sleep bruxism (SB), associating these characteristics with the quality of sleep. For this, we followed the International Classification of Sleep Disorders for the diagnosis of SB, in addition to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) for the classification of TMD and cone beam computed tomography. It was found that 97.7% of the individuals with bruxism had at least 1 RDC/TMD group III diagnosis, 75.6% o... περισσότερα »
The Affordable Care Act: Opportunities and Challenges for Physicians.
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 58 δευτερόλεπτα
The Affordable Care Act (ACA) will affect many aspects of health care across the nation, presenting both opportunities and challenges. Physicians who have a solid understanding of the recent industry trends and the role they will be playing in the post-ACA world will be able to better adapt to the new environment. This article analyzes the implications of the health care reform for physicians and offers recommendations on how to turn challenges into opportunities. (C) 2015 by Mutaz B. Habal, MD. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1MPFp6L via IFTTT
Residents' Perceptions of Plastic Surgeons as Craniofacial Surgery Specialists.
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 58 δευτερόλεπτα
Objective: To assess residents' perceptions of plastic surgeons as craniofacial surgery specialists in Brazil. Methods: Brazilian residents were asked to choose 1 or 2 specialists that they perceived to be an expert for 14 craniofacial surgery-related scenarios. Both an overall analysis (all 14 scenarios) and subanalysis (each scenario separately) were performed. Response patterns were distributed as "plastic surgeons alone," "plastic surgeons combined with other specialists," or "without plastic surgeons." Results: Overall, plastic surgeons were chosen more (all P from OroFacial Me... περισσότερα »
Effects of Obstructive Sleep Apnea in Children as a Result of Adenoid and/or Adenotonsillar Hypertrophy on Maternal Psychologic Status.
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 58 δευτερόλεπτα
The authors aimed to evaluate the effects of obstructive sleep apnea in children as a result of adenoid and/or adenotonsillar hypertrophy on maternal psychologic status. The study sample comprised the mothers of 66 children aged 3 to 15 years (mean age: 7.55 +/- 2.94 years) who were scheduled to undergo curette adenoidectomy or adenotonsillectomy because of airway obstruction. The mothers completed the 14-item Hospital Anxiety and Depression Scale (HADS), 20-item State-Trait Anxiety Inventory-1 (STAI-1), and 20-item State-Trait Anxiety Inventory-2 (STAI-2) questionnaires before the ... περισσότερα »
Composite Orbital Reconstruction
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Using the Vascularized Segmentalized Osteo-Fascio-Cutaneous Fibula Flap by T.Kalle Lundgren, Marco Pignatti, Martin Halle, Giulia Boscaini, Ann-Charlotte Docherty Skogh, M.D. Giorgio De Santis viaPlastic, Reconstructive & Aesthetic Surgery Reconstruction of composite orbital defects must address the orbit and an exposed skull base and/or maxillary region. The orbit should not only be covered but also reshaped to accomodate the orbital contents or an epithesis when needed. A rationale for a near anatomical reconstruction of the orbit, together with adjacent dead space obliteration, us...περισσότερα »
Improving Quality of Life With Nabilone During Radiotherapy Treatments
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial by Cote, M., Trudel, M., Wang, C., Fortin, A. via Annals of Otology, Rhinology & Laryngology RSS feed -- OnlineFirst Articles Objectives:Patients treated for head and neck carcinomas experience a significant deterioration of their quality of life during treatments because of severe side effects. Nabilone has many properties that could alleviate symptoms caused by radiotherapy and improve patients’ quality of life. The aim of the present study was to compare the effects of nabilone versus placebo on the qua... περισσότερα »
Periodic leg movements in sleep (PLMS)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Inter-movement interval as a primary stable measure of periodic limb movements of sleepPatrick Skeba, Kasidet Hiranniramol, Christopher J Earley, Richard P Allen, 2015-10-27 09:13:01 AM Highlights • PLMS/hr is not a stable measure between consecutive nights (50% change) • Intermovement intervals (IMI) of PLMS distribution approximates a log normal • The mean of log IMI of PLMS is a stable between consecutive nights (4-8% change) • Mean log IMI of PLMS measures period of the biological PLMS generator • Mean log IMI characterizes the PLMS biology independent of sleep disturbance Abstract... περισσότερα »
Regenerative Peripheral Nerve Interface for Prostheses Control
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
: Electrode Comparison by Sando, Ian C. via Journal of Reconstructive Microsurgery J reconstr Microsurg DOI: 10.1055/s-0035-1565248 Background This study compared epimysial patch electrodes with intramuscular hook electrodes using monopolar and bipolar recording configurations. The purpose was to determine which strategy transduced muscle signals with better fidelity for control of myoelectric prostheses. Methods One of the two electrode styles, patch (n = 4) or hook (n = 6) was applied to the left extensor digitorum longus muscle in rats. Electrodes were evaluated at the time of plac...περισσότερα »
Only new daily persistent headache patients with risk factors (cardiovascular/cerebrovascular or migraine) developed white matter abnormalities
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
New daily persistent headache: A lack of an association with white matter abnormalities on neuroimagingRozen, T. D., 2015-10-27 08:56:05 AM Objective To provide results from the largest study of new daily persistent headache patients to date and specifically evaluate if patients with primary new daily persistent headache develop white matter abnormalities or infarct-like lesions on neuroimaging. Methods Retrospective analysis of patient medical records utilizing an electronic medical record system. All patients were seen at a headache specialty clinic by a single headache neurologist ...περισσότερα »
Habituation of visual-evoked potentials (VEPs) is typically described as deficient interictally in migraine patients, supposedly indicating altered cortical excitability
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Test-retest reliability of visual-evoked potential habituationRauschel, V., Ruscheweyh, R., Krafczyk, S., Straube, A., 2015-10-27 08:56:05 AM Objective Habituation of visual-evoked potentials (VEPs) is typically described as deficient interictally in migraine patients, supposedly indicating altered cortical excitability. Use of this parameter for monitoring changes over time, e.g. under treatment, requires demonstration of test-retest reliability. Methods VEPs were recorded interictally in 41 episodic migraine patients and 40 controls. N75–P100 amplitudes were measured over six consec... περισσότερα »
Auditory Perception and Production of Speech Feature Contrasts by Pediatric Implant Users
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
[image: image]Objective: The aim of the present research is to examine the relations between auditory perception and production of specific speech contrasts by children with cochlear implants (CIs) who received their implants before 3 years of age and to examine the hierarchy of abilities for perception and production for consonant and vowel features. The following features were examined: vowel height, vowel place, consonant place of articulation (front and back), continuance, and consonant voicing. Design: Fifteen children (mean age = 4;0 and range 3;2 to 5;11) with a minimum of 18... περισσότερα »
Self-Reported Hearing Difficulties Among Adults With Normal Audiograms: The Beaver Dam Offspring Study
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
[image: image]Objective: Clinicians encounter patients who report experiencing hearing difficulty (HD) even when audiometric thresholds fall within normal limits. When there is no evidence of audiometric hearing loss, it generates debate over possible biomedical and psychosocial etiologies. It is possible that self-reported HDs relate to variables within and/or outside the scope of audiology. The purpose of this study is to identify how often, on a population basis, people with normal audiometric thresholds self-report HD and to identify factors associated with such HDs. Design: Thi... περισσότερα »
Social Support Predicts Hearing Aid Satisfaction
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
[image: image]Objectives: The goals of the current research were to determine: (1) whether there is a relationship between perceived social support and hearing aid satisfaction, and (2) how well perceived social support predicts hearing aid satisfaction relative to other correlates previously identified in the literature. Design: In study 1, 173 adult ( age = 68.9 years; SD = 13.4) users of hearing aids completed a survey assessing attitudes toward health, hearing, and hearing aids, as well as a questionnaire assessing Big-Five personality factors (Openness to Experience, Conscienti... περισσότερα »
Sleep Medicine
Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 1 ώρα
- Inter-movement interval as a primary stable measure of periodic limb movements of sleepPatrick Skeba, Kasidet Hiranniramol, Christopher J Earley, Richard P Allen, 2015-10-27 09:13:01 AM • PLMS/hr is not a stable measure between consecutive nights (50% change)• Intermovement intervals (IMI) of PLMS distribution approximates a log normal• The mean of log IMI of PLMS is a stable between consecutive nights (4-8% change)• Mean log IMI of PLMS measures period of the biological PLMS generator• Mean log IMI characterizes the PLMS biology independent of sleep disturbance Rea...περισσότερα »
Risk stratification in acute upper GI bleeding: comparison of the AIMS65 score to the Glasgow-Blatchford and Rockall scoring systems
Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 1 ώρα
The American College of Gastroenterology recommends early risk stratification in patients presenting with upper gastrointestinal bleeding (UGIB). AIMS65 is a risk stratification score previously validated to predict inpatient mortality. The aim of this study was to validate the AIMS65 score as a predictor of inpatient mortality in patients with acute UGIB and to compare it with established pre-endoscopy and post-endoscopy risk scores. from Endocrinology via ola Kala on Inoreader http://ift.tt/1LTGpqM via IFTTT
Die adjuvante Nachbestrahlung reduziert die Lokalrezidivrate auch beim prognostisch günstigen DCIS der Brust signifikant
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
from Pharmacology via ola Kala on Inoreader http://ift.tt/1Guua76 via IFTTT
Temporal changes in tumor oxygenation and perfusion upon normo- and hyperbaric inspiratory hyperoxia
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Abstract Background Inspiratory hyperoxia under hyperbaric conditions has been shown to effectively reduce tumor hypoxia and to improve radiosensitivity. However, applying irradiation (RT) under hyperbaric conditions is technically difficult in the clinical setting since RT after decompression may be effective only if tumor pO2 remains elevated for a certain period of time. The aim of the present study was to analyze the time course of tumor oxygenation and perfusion during and after hyperbaric hyperoxia. Materials and methods Tumor oxygenation, red blood cell (RBC) flux for perfu... περισσότερα »
Miravirsen dosing in chronic hepatitis C patients results in decreased microRNA-122 levels without affecting other microRNAs in plasma
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Summary Background MicroRNA-122 (miR-122) is an important host factor for hepatitis C virus replication. Administration of miravirsen, an anti-miR-122 oligonucleotide, resulted in a dose dependent and prolonged decrease in HCV RNA levels in chronic hepatitis C patients. Aim To assess the plasma level of various miRNAs in patients dosed with miravirsen. Methods We included 16 of 36 chronic hepatitis C patients who received five injections of either 3 mg/kg (*n* = 4), 5 mg/kg (*n* = 4), 7 mg/kg (*n* = 4) miravirsen or placebo (*n* = 4) over a 4-week period in a double-blind, ran... περισσότερα »
Journal of Reconstructive Microsurgery
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
- Regenerative Peripheral Nerve Interface for Prostheses Control: Electrode ComparisonSando, Ian C., 2015-10-27 09:11:07 AM J reconstr Microsurg DOI: 10.1055/s-0035-1565248 Background This study compared epimysial patch electrodes with intramuscular hook electrodes using monopolar and bipolar recording configurations. The purpose was to determine which strategy transduced muscle signals with better fidelity for control of myoelectric prostheses. Methods One of the two electrode styles, patch (n = 4) or hook (n = 6) was applied to the left extensor digit... περισσότερα »
Robust time-series retrieval using probabilistic adaptive segmental alignment
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα
Abstract Traditional pairwise sequence alignment is based on matching individual samples from two sequences, under time monotonicity constraints. However, in many application settings, matching subsequences (segments) instead of individual samples may bring in additional robustness to noise or local non-causal perturbations. This paper presents an approach to segmental sequence alignment that jointly segments and aligns two sequences, generalizing the traditional per-sample alignment. To accomplish this task, we introduce a distance metric between segments based on average pairwise...περισσότερα »
Evaluation of Relationship Between Body Dysmorphic Disorder and Self-Esteem in Rhinoplasty Candidates.
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Aim: To investigate the relationship between body dysmorphic syndrome and self-esteem in rhinoplasty candidates. Results: A negative statistical correlation was evident between Rosenberg Self-Esteem Scale (RSES) and Body Dysmorphic Disorder Examination-Self Report (BDDE-SR) scores. In terms of responses to the first Body Dysmorphic Disorder Questionnaire (BDDQ) question, which focuses on general attitude toward body dysmorphic syndrome, the average RSES "YES" score was significantly less than the "NO" score. No significant differences appeared between RSES scores and scores for the ... περισσότερα »
Microvascular Decompression for Trigeminal Neuralgia: Zone Exploration and Decompression Techniques.
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Objective: The aim of this study is to introduce zone exploration of the trigeminal nerve and decompression techniques for different types of vasculars. Methods: The trigeminal nerve was sectioned into 5 zones. Zone 1, 2, 3, 4 was located at the rostral, caudal, ventral, and dorsal part of the nerve root entry zone (REZ) respectively, and zone 5 was located at the distal of the nerve root. This study contained 86 patients with trigeminal neuralgia underwent microvascular decompression. Every zone was exposed through preoperative imaging. During the operation, offending vessels were ... περισσότερα »
Development of Technical Skills: Education, Simulation, and Maintenance of Certification.
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
The goal of this article is to provide a focused overview of technical skills education inside the operating room (OR), opportunities for learning outside of the OR (with a focus on simulation), and methods for measuring technical skills. In addition, the authors review the role of maintenance of certification in continuing education and quality improvement and consider the role that simulation plays in this process. The perspectives on teaching in the OR of both residents and faculty going into the case affect the learning environment, and preoperative interactions between attendin... περισσότερα »
Genetic analysis of environmental strains of the plant pathogen Phytophthora capsici reveals heterogeneous repertoire of effectors and possible effector evolution via genomic island
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
*Phytophthora capsici* is a virulent oomycete pathogen of many vegetable crops. Recently, it has been demonstrated that the recognition of the RXLR effector AVR3a1 of *P. capsici* (PcAVR3a1) triggers a hypersensitive response and plays a critical role in mediating non-host resistance. Here, we analyzed the occurrence of PcAVR3a1 in 57 isolates of *P. capsici* derived from globe squash, eggplant, tomato and bell pepper cocultivated in a small geographical area. The occurrence of PcAVR3a1 in environmental strains of *P. capsici* was confirmed by PCR in only 21 of these pathogen isol... περισσότερα »
Revisiting bacterial cyclic nucleotide phosphodiesterases: cyclic AMP hydrolysis and beyond
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Cyclic-3',5'-adenosine monophosphate (cAMP) is a universal second messenger that regulates vital activities in bacteria and eukaryotes. Enzymes that hydrolyze cAMP, called phosphodiesterases (PDEs), negatively regulate the levels of this messenger molecule and are therefore crucial for signal 'termination'. In this minireview, I shall summarize the available literature on bacterial cAMP-PDEs, with particular emphasis on enzymes belonging to the ubiquitously encoded Class III PDE family exemplified by CpdA from *Escherichia coli* and Rv0805 from *Mycobacterium tuberculosis*. Using ...περισσότερα »
Production of autoinducer-2 by aerobic endospore-forming bacteria isolated from the West African fermented foods
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Autoinducer-2 (AI-2) is a quorum-sensing (QS) molecule which mediates interspecies signaling and affects various bacterial behaviors in food fermentation. Biosynthesis of AI-2 is controlled by S-ribosylhomocysteine lyase encoded by the *luxS* gene. The objective of this study was to investigate production of AI-2 by aerobic endospore-forming bacteria (AEB) isolated from the West African alkaline fermented seed products *Mantchoua* and *Maari*. The study included 13 AEB strains of *Bacillus subtilis*, *B. cereus*, *B. altitudinis*, *B. amyloliquefaciens*, *B. licheniformis*, *B. ar... περισσότερα »
Variability of the characteristics of a migraine attack
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
within patientsViana, M., Sances, G., Ghiotto, N., Guaschino, E., Allena, M., Nappi, G., Goadsby, P., Tassorelli, C., 2015-10-27 08:56:05 AM Background Migraine attacks may present different features in different patients and also within the same patient. The percentage of patients reporting stereotyped attacks and those reporting attacks with different phenotypes has not been the object of specific investigations. Objective The objective of this article is to evaluate the percentage of migraine patients reporting the same characteristics, in terms of phenotype and response to sympto...περισσότερα »
Genetic constitution on migraine drug responses
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The influence of genetic constitution on migraine drug responsesChristensen, A. F., Esserlind, A.-L., Werge, T., Stefansson, H., Stefansson, K., Olesen, J., 2015-10-27 08:56:05 AM Objective Specific acute treatments of migraine are 5HT1B/D receptor agonists; triptans and ergotamine, but only two-thirds of patients respond well without side effects. No migraine-prophylactic drugs are specific to migraine. Prophylactic drugs are selected by time-consuming "trial and error." Personalized treatment is therefore much needed. The objective of this study was to test the effect of 12 single ...περισσότερα »
Antineutrophil cytoplasmic antibody (ANCA)–associated small-vessel vasculitis associated with antithyroid drugs (ATD)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Antineutrophil Cytoplasmic Antibody–Positive Small-Vessel Vasculitis Associated with Antithyroid Drug Therapy: How Significant Is the Clinical Problem? *To cite this article:* Balavoine Anne-Sophie, Glinoer Daniel, Dubucquoi Sylvain, and Wémeau Jean-Louis. Thyroid. -Not available-, ahead of print. doi: 10.1089/thy.2014.0603 Author information Anne-Sophie Balavoine,1,* Daniel Glinoer,2 Sylvain Dubucquoi,3 and Jean-Louis Wémeau1,3 1Service of Endocrinology and Metabolic Diseases, CHRU de Lille, Lille, France. 2Department of Internal Medicine, Division of Endocrinology, University Hospit...περισσότερα »
Small Fiber Neuropathy in Fibromyalgia Pain
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The Role and Importance of via Latest Results for Current Pain and Headache Reports AbstractSerious investigators of fibromyalgia (FM) realize the profound implications of finding features of small fiber neuropathy (SFN) in this disorder. For the first time, an easily reproducible and generally agreed upon, peripheral tissue lesion has been reported from multiple investigative centers. Understanding how this discovery relates to other features of FM, and how one might utilize it to better comprehend, and care for, afflicted patients’ painful complaints remains a challenge, however. ... περισσότερα »
COI for American Thyroid Association Statement on Surgical Application of Molecular Profiling for Thyroid Nodules
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Response to Letter to the Editor on COI for American Thyroid Association Statement on Surgical Application of Molecular Profiling for Thyroid Nodules *To cite this article:* Ferris Robert L., Carty Sally E., and on behalf of the ATA Surgical Affairs Committee Co-Chairs and the Consensus Statement Writing Group. Thyroid. -Not available-, ahead of print. doi:10.1089/thy.2015.0446 - Full Text HTML - Full Text PDF (36.6 KB) - Full Text PDF with Links (39.6 KB) Author information Robert L. Ferris1 and Sally E. Carty2 on behalf of the ATA Surgical Affairs Committee Co-Chairs and...περισσότερα »
Relapsed Graves' Disease Patients Following Radioiodine or Prolonged Low Dose of Methimazole Treatment
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Outcomes in Relapsed Graves' Disease Patients Following Radioiodine or Prolonged Low Dose of Methimazole Treatment *To cite this article:* Villagelin Danilo, Romaldini João H., Santos Roberto B., Milkos Ana B.B.P., and Ward Laura S.. Thyroid. -Not available-, ahead of print. doi: 10.1089/thy.2015.0195 Author information Danilo Villagelin,1,2 João H. Romaldini,1,3 Roberto B. Santos,1 Ana B.B.P. Milkos,3 and Laura S. Ward2 1Endocrinology and Metabolism, School of Medicine, Pontifical University Catholic of Campinas, Campinas, Brazil. 2Laboratory of Cancer Molecular Genetics, School of Med... περισσότερα »
Follicular thyroid carcinoma (FTC) comprises 10% of differentiated thyroid cancers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Follicular Thyroid Carcinoma: How Have Histologic Diagnoses Changed in the Last Half-Century and What Are the Prognostic Implications? *To cite this article:* Cipriani Nicole A., Nagar Sapna, Kaplan Sharone P., White Michael G., Antic Tatjana, Sadow Peter M., Aschebrook-Kilfoy Briseis, Angelos Peter, Kaplan Edwin L., and Grogan Raymon H.. Thyroid. -Not available-, ahead of print. doi:10.1089/thy.2015.0297 Author information Nicole A. Cipriani,1* Sapna Nagar,2* Sharone P. Kaplan,3 Michael G. White,3 Tatjana Antic,1 Peter M. Sadow,4 Briseis Aschebrook-Kilfoy,5 Peter Angelos,3 Edwin L. K... περισσότερα »
Web-Based Malignancy Risk Estimation for Thyroid Nodules Using Ultrasonography Characteristics
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
: Development and Validation of a Predictive Model by Young Jun Choi via liebertpub1 Thyroid , Vol. 0, No. 0. Author information Young Jun Choi,1 Jung Hwan Baek,1 Seung Hee Baek,2 Woo Hyun Shim,1 Kang Dae Lee,3 Hyoung Shin Lee,3 Young Kee Shong,4 Eun Ju Ha,5 and Jeong Hyun Lee1 1Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Seoul, Korea. 2Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 3Department of Otolaryngology—Head and Neck Surgery, Kosin Univer... περισσότερα »
Potential signs of aspiration in preterm infants
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
A Retrospective Examination of Prandial Aspiration in Preterm Infants by Ferguson NF, Estis J, Evans K, et al. via Perspectives on Swallowing and Swallowing Disorders (Dysphagia) Current Issue Purpose We conducted this retrospective study to identify potential signs of aspiration in preterm infants based on crib-side nursing documentation. Study Design and Methods A total of 2,590 bottle-feedings were examined for signs of distress across 41 preterm infants who were referred for a swallowing evaluation. All infants underwent either a videofluoroscopic swallow study (VSS) or upper gastr... περισσότερα »
To assess Allergic rhinitis (AR), with a visual analogue scale (VAS) score
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
A common language to assess allergic rhinitis control: results from a survey conducted during EAACI 2013 Congress by Peter Hellings via Allergy Background: The concept of control is gaining importance in the field of allergic rhinitis (AR), with a visual analogue scale (VAS) score being a validated, easy and attractive tool to evaluate AR symptom control. The doctors’ perception of a VAS score as a good tool for evaluating AR symptom control is unknown, as is the level of AR control perceived by physicians who treat patients. Methods: 307 voluntarily selected physicians attending the... περισσότερα »
Omalizumab treatment has been related to the suppression of the high-affinity IgE receptor (FcεRI) on plasmacytoid dendritic cells (DCs)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The dendritic cell high-affinity IgE receptor is overexpressed both in asthma and severe COPD by Paul Stoll, Anne Bähker, Martin Ulrich, Kai Bratke, Katharina Garbe, J. Christian Virchow, Marek Lommatzsch via Clinical & Experimental Allergy Abstract Background The reduction of asthma exacerbations following omalizumab treatment has been related to the suppression of the high-affinity IgE receptor (FcεRI) on plasmacytoid dendritic cells (DCs). However, the FcεRI expression on DCs in chronic obstructive pulmonary disease (COPD) is unknown. Objective To compare FcεRI expression on DCs in ... περισσότερα »
Swallowing and Swallowing Disorders (Dysphagia) Current Issue
Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
- Editor's ColumnSimon M. , 2015-10-01 02:00:00 AM Read moreTop - Informed Consent in Clinical and Research Settings: What Do Patients and Families Need to Make Informed Decisions?Sharp HM. , 2015-10-01 02:00:00 AM Informed consent requires that patients in clinical settings and participants in research voluntarily agree to a proposed plan based on their understanding of a clear and thorough explanation of purpose, risks, benefits, and alternatives. Although the need to obtain informed consent is well understood in clinical and research environments, th... περισσότερα »
Clinical and Translational Allergy - Latest Articles
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 1 ώρα
A common language to assess allergic rhinitis control: results from a survey conducted during EAACI 2013 Congress Background: The concept of control is gaining importance in the field of allergic rhinitis (AR), with a visual analogue scale (VAS) score being a validated, easy and attractive tool to evaluate AR symptom control. The doctors’ perception of a VAS score as a good tool for evaluating AR symptom control is unknown, as is the level of AR control perceived by physicians who treat patients. Methods: 307 voluntarily selected physicians attending the annual (2013) European Acade...περισσότερα »
Clinical & Experimental Allergy
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 1 ώρα
- Effects of conventional tobacco smoke and nicotine-free cigarette smoke on airway inflammation, airway remodeling and lung function in a triple allergen model of severe asthmaCornelia Tilp, Hannes Bucher, Hannah Haas, Matthias J. Duechs, Eva Wex, Klaus J. Erb, 2015-10-27 08:28:05 AM Summary Background Patients with asthma who smoke have reduced lung function, increased exacerbation rates and increased steroid resistance compared to non-smoking asthmatics. In mice, cigarette smoke has been reported to have both pro- and anti-Th2 response effects. ... περισσότερα »
Airway inflammation, airway remodeling and lung function in a triple allergen model of severe asthma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Effects of conventional tobacco smoke and nicotine-free cigarette smoke on airway inflammation, airway remodeling and lung function in a triple allergen model of severe asthma by Cornelia Tilp, Hannes Bucher, Hannah Haas, Matthias J. Duechs, Eva Wex, Klaus J. Erb via Clinical & Experimental Allergy Summary Background Patients with asthma who smoke have reduced lung function, increased exacerbation rates and increased steroid resistance compared to non-smoking asthmatics. In mice, cigarette smoke has been reported to have both pro- and anti-Th2 response effects. Objective We hypothesiz... περισσότερα »
A port wine stain (PWS) is a type of capillary vascular malformation composed of malformed, dilated blood vessels within the papillary and reticular dermis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Port wine stain treated with a combination of pulsed dye laser and topical rapamycin ointment by Thomas D. Griffin, James P. Foshee, Robert Finney, Nazanin Saedi via Lasers in Surgery and Medicine Background and Objective A port wine stain (PWS) is a type of capillary vascular malformation composed of malformed, dilated blood vessels within the papillary and reticular dermis. Currently, pulsed dye laser (PDL) is considered the therapeutic gold standard, although greater than 90% of lesions may be refractory to treatment. Studies have shown that a delay in treatment results in a highe... περισσότερα »
Lasers in Surgery and Medicine
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
- Port wine stain treated with a combination of pulsed dye laser and topical rapamycin ointmentThomas D. Griffin, James P. Foshee, Robert Finney, Nazanin Saedi, 2015-10-27 08:21:17 AM Background and Objective A port wine stain (PWS) is a type of capillary vascular malformation composed of malformed, dilated blood vessels within the papillary and reticular dermis. Currently, pulsed dye laser (PDL) is considered the therapeutic gold standard, although greater than 90% of lesions may be refractory to treatment. Studies have shown that a delay in treatment ... περισσότερα »
Radiologische Bildgebung und Strahlenexposition in der Mund-, Kiefer- und Gesichtschirurgie
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
Zusammenfassung Die (natürliche und zivilisatorische) Gesamtstrahlenbelastung der Bevölkerung in Deutschland (kollektive effektive Dosis) pro Person betrug im Jahre 2012 4 mSv. Die durchschnittliche Strahlenbelastung aus medizinischer Indikation macht mit 1,9 mSv den Hauptanteil der zivilisatorischen Strahlenquellen aus. Effektive Behandlungsplanungen sollten Doppeluntersuchungen vermeiden. Von besonderer Bedeutung ist dies bei Kindern und Jugendlichen. Für viele Fragestellungen ist die digitale Volumentomographie der CT vorzuziehen. from #Aesthetics via alexandrossfakianakis on ...περισσότερα »
Commentary on: Labia Minora, Labia Majora, and Clitoral Hood Alteration: Experience-Based Recommendations
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1MfPqJK via IFTTT
The Nonexistent
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1P29OTZ via IFTTT
On Music
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1P29QLz via IFTTT
Composite Orbital Reconstruction Using the Vascularized Segmentalized Osteo-Fascio-Cutaneous Fibula Flap
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
Reconstruction of composite orbital defects must address the orbit and an exposed skull base and/or maxillary region. The orbit should not only be covered but also reshaped to accomodate the orbital contents or an epithesis when needed. A rationale for a near anatomical reconstruction of the orbit, together with adjacent dead space obliteration, using the segmentalized osteo-fascia-cutaneous fibula flap is presented. Before flap transfer a cutting-template for the fibula is made according to the measures and requirements of the facial defect. from #Aesthetics via alexandrossfakian... περισσότερα »
The Kinect Recording System for Objective Three- and Four-Dimensional Breast Assessment with Image Overlays
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
We investigated the application of the validated portable Kinect camera for three-and fourdimensional breast assessment in female life models. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1PQPxBm via IFTTT
Serum Levels of Renin, Angiotensin Converting Enzyme and Angiotensin II in Patients Treated by Surgical Excision, Propranolol and Captopril for Problematic Proliferating Infantile Haemangioma
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
The role of the renin-angiotensin system (RAS) in the biology of infantile haemangioma (IH) and its accelerated involution induced by β-blockers was initially proposed in 2010. This led to the first clinical trial in 2012 using low-dose captopril, an angiotensin converting enzyme inhibitor, demonstrating a similar response in these tumours. The current study aimed to compare serial serum levels of the components of the RAS in patients before and after surgical excision, propranolol or captopril treatment for problematic proliferating IH. from #Aesthetics via alexandrossfakianakis ... περισσότερα »
Has Angelina Jolie effect Led to an Increase in Risk Reducing Mastectomy and Breast Reconstruction in Wales; a Retrospective, Single Centre Cohort Study
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 1 ώρα
On 14th May 2013, Hollywood actress Angelina Jolie made public her prophylactic double mastectomy and reconstruction because she carries the BRCA gene mutation. Following this publicity, referrals to the All Wales Genetics Service nearly doubled in 2013 compared with 2012 1. This coincided with the issue of newly revised NICE guidance on familial breast cancer that was ratified in June 2013 2. This increase in demand for genetic screening was labelled the Angelina Jolie effect 1. We undertook this study to see whether this Angelina Jolie effect has also led to an increase in patie... περισσότερα »
Cosmetic Injectable Fillers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
1. - Cosmetic Injectable Fillers - *Page i* - *Corey S. Maas* - - * Purchase PDF - $31.50* - * Not entitled to full text* 2. - - Copyright - *Page ii* - - - * Purchase PDF - $31.50* - * Not entitled to full text* 3. - - Contributors - *Page iii* - - - * Purchase PDF - $31.50* - * Not entitled to full text* 4. - - Contents - *Pages v-vii* - - - * PDF (109 K)* - * Entitled to full text* 5...περισσότερα »
Unintentional Injection of Soft Tissue Filler into Blood Vessels in the Face: FDA Safety Communication
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm448255.htm *Date Issued: *May 28, 2015 *Audiences:* - Health care providers who inject patients with facial soft tissue fillers - Health care providers who treat patients following unintentional injection of soft tissue fillers into blood vessels - People considering, or who have had, procedures that use soft tissue fillers *Specialties: *Dermatologists, plastic surgeons, cosmetic surgeons, dentists, and other medical providers who treat patients using soft tissue fillers; other health care providers who m... περισσότερα »
Epitope targeted anthrax vaccine
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Presentation of peptides from Bacillus anthracis protective antigen on Tobacco Mosaic Virus as an epitope targeted anthrax vaccine via ScienceDirect Publication: Vaccine Publication date: Available online 26 October 2015 *Source:*Vaccine Author(s): Ryan C. McComb, Chi-Lee Ho, Kenneth A. Bradley, Laurence K. Grill, Mikhail Martchenko The current anthrax vaccine requires improvements for rapidly invoking longer-lasting neutralizing antibody responses with fewer doses from a well-defined formulation. Designing antigens that target neutralizing antibody epitopes of anthrax protective antig...περισσότερα »
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