Medicine

Reconstruction of Rare Skull Metastases Using Free Latissimus Dorsi Flap and the Role of Preoperative Embolization in Hypervascular Skull Tumors.

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες

Metastatic tumors are the most common cranial neoplasms in adults. Skull metastases from rare primary tumors, such as cholangiocarcinoma or pancreatic neuroendocrine tumor, are extremely uncommon and rarely reported. Given the scarcity and variation of these rare skull metastases, treatments and outcomes of such patients are of interest to treating surgeons. The authors describe the treatment algorithm, course, and outcomes of 2 patients with rare gastrointestinal skull metastases. The first patient had intrahepatic cholangiocarcinoma metastatic to the skull, while the second patien...περισσότερα »

Interaction of Methanol Spray and Water Deficit Stress on Photosynthesis and Biochemical Characteristics of Phaseolus vulgaris L. cv. Sadry

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες

Abstract This study was a factorial experiment with a completely randomized design and three replications. The four levels of methanol spraying were used. Spraying was carried out three times during the growing season at 10 d intervals beginning at 4 wk after sowing. The spraying of solution continued until saturation of droplets on the leaves was achieved. The levels of water deficit stress applied were non-stress, moderate water stress and severe water stress. The results showed there was a significant difference (p ≤ 0.05) between the methanol and water deficit stress treatment... περισσότερα »

Japanese Cedar ( Cryptomeria japonica ) pollen allergen induces elevation of intracellular calcium in human keratinocytes and impairs epidermal barrier function of human skin ex vivo

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες

Abstract Cry j1 is the major peptide allergen of Japanese cedar (Sugi), *Cryptomeria japonica*. Since some allergens disrupt epidermal permeability barrier homeostasis, we hypothesized that Cry j1 might have a similar effect. Intracellular calcium level in cultured human keratinocytes was measured with a ratiometric fluorescent probe, Fura-2 AM. Application of Cry j1 significantly increased the intracellular calcium level of keratinocytes, and this increase was inhibited by trypsin inhibitor or a protease-activated receptor 2 (PAR-2) antagonist. We found that Cry j1 itself did not... περισσότερα »

Diversity of pigmented Gram-positive bacteria associated with marine macroalgae from Antarctica

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 2 ώρες

Little is known about the diversity and roles of Gram-positive and pigmented bacteria in Antarctic environments, especially those associated with marine macroorganisms. This work is the first study about the diversity and antimicrobial activity of culturable pigmented Gram-positive bacteria associated with marine Antarctic macroalgae. A total of 31 pigmented Gram-positive strains were isolated from the surface of six species of macroalgae collected in the King George Island, South Shetland Islands. On the basis of 16S rRNA gene sequence similarities ≥99%, 18 phylotypes were define... περισσότερα »

The Role of Elective Amputation In Patients With Traumatic Brachial Plexus Injury

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 2 ώρες

Despite undergoing complex brachial plexus surgical reconstructions and rehabilitation, some patients request an elective amputation. This study evaluates the role of elective amputation after brachial plexus injury. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1S7jNaA via IFTTT

Thin Melanomas (

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 2 ώρες

New melanoma diagnoses numbered 13,348 cases in 2011, with thin melanomas (Breslow thickness < 1mm) accounting for more than half.1,2 Recently published melanoma guidance from the National Institute for Health and Clinical Excellence (NICE) does not recommend sentinel lymph node biopsy (SLNB) for any melanoma ≤1mm Breslow thickness.1 from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1PQPuFU via IFTTT

Updated Global Meningococcal Initiative (GMI) recommendations

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

The current situation of meningococcal disease in Latin America and updated Global Meningococcal Initiative (GMI) recommendations via ScienceDirect Publication: Vaccine Publication date: Available online 25 October 2015 *Source:*Vaccine Author(s): Marco Aurélio P. Sáfadi, Miguel O’Ryan, Maria Teresa Valenzuela Bravo, Maria Cristina C. Brandileone, Maria Cecília O. Gorla, Ana Paula S. de Lemos, Gabriela Moreno, Julio A. Vazquez, Eduardo L. López, Muhamed-Kheir Taha, Ray Borrow The Global Meningococcal Initiative (GMI) was established in 2009 and comprises an international team of scient... περισσότερα »

Prevention and treatment of sepsis : Detoxified LPS/group B meningococcal outer membrane protein vaccine with and without synthetic CPG 7909 adjuvant

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Phase 1 testing of detoxified LPS/group B meningococcal outer membrane protein vaccine with and without synthetic CPG 7909 adjuvant for the prevention and treatment of sepsis via ScienceDirect Publication: Vaccine Publication date: Available online 26 October 2015 *Source:*Vaccine Author(s): Alan S. Cross, Nancy Greenberg, Melissa Billington, Lei Zhang, Christopher DeFilippi, Ryan C. May, Kanwaldeep K. Bajwa BackgroundGram-negative bacteria (GNB) are a leading cause of nosocomial infection and sepsis. Increasing multi-antibiotic resistance has left clinicians with fewer therapeutic opt...περισσότερα »

Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review by Yasueda, A., Urushima, H., Ito, T. via Integrative Cancer Therapies RSS feed -- OnlineFirst Articles Oxidative stress is a key component in carcinogenesis. Although radiation produces reactive oxygen species, some anticancer agents such as alkylating agents, platinum and antitumor antibiotics exert cytotoxicity by generating free radicals. Nonenzymatic exogenous antioxidants such as vitamins, minerals, and polyphenols can quench ROS activity. However, whether antioxidan... περισσότερα »

Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Malignant and Benign Thyroid Lesions

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions via http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12253&channel-name=Pathology+%26+Oncology+Research AbstractHu-antigen R (HuR) is considered to play a crucial role in tumor formation and growth by binding to mRNAs encoding proteins such as Cyclooxygenase-2 (COX-2) and inducing their expression via mRNA stabilization and/or altered translation. The present study aimed to evaluate the clinical significance of HuR and ... περισσότερα »

Brimonidine tartrate for the treatment of rosacea

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 3 ώρες

Jackson JM, Knuckles M, Minni JP, Johnson SM, Belasco KT from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1S7v7U4 via IFTTT

Clinical Effectiveness of Mupirocin for Preventing Staphylococcus aureus Infections in Non-Surgical Settings: A Meta-Analysis

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες

A meta-analysis, conducted to evaluate the clinical effectiveness of decolonization in non-surgical settings, demonstrated reduced risk for *S. aureus* infections among non-dialysis and dialysis patients treated with mupirocin. Studies were observed to be heterogeneous despite conducting subgroup and stratified analyses. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1LYT9zS via IFTTT

Six-week Combination Directly Acting Anti-HCV Therapy Induces Moderate Rates of Sustained Virologic Response in Patients with Advanced Liver Disease

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες

Fifty treatment naïve and experienced genotype-1 patients with advanced fibrosis were treated for six weeks with LDV/SOF plus a third directly acting antiviral, resulting in a 76% response rate. Significant liver fibrosis remains a limitation of short duration DAA therapy. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1RaJtSY via IFTTT

Cost-effectiveness evaluation of quadrivalent influenza vaccines for seasonal influenza prevention: a dynamic modeling study of Canada and the United Kingdom

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες

Background: The adoption of quadrivalent influenza vaccine (QIV) to replace trivalent influenza vaccine (TIV) in immunization programs is growing worldwide, thus helping to address the problem of influenza B lineage mismatch. However, the price per dose of QIV is higher than that of TIV. In such circumstances, cost-effectiveness analyses provide important and relevant information to inform national health recommendations and implementation decisions. This analysis assessed potential vaccine impacts and cost-effectiveness of a country-wide switch from TIV to QIV, in Canada and the ... περισσότερα »

Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and proteinuria predict severity of acute kidney injury in Puumala virus infection

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες

Background: Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome (HFRS) that is caused by the Puumala virus. Periodic outbreaks have been described in endemic areas, with a substantial number of previously healthy individuals developing acute kidney injury (AKI). There is a considerable diversity in the clinical course of the disease, and few patients require renal replacement therapy. Methods: We tested whether urinary neutrophil gelatinase associated lipocalin (uNGAL), urine albumin/creatinine ratio (uACR), urine protein/creatinine ratio (uPCR), ur... περισσότερα »

Echinocystic Acid Inhibits IL-1β-Induced COX-2 and iNOS Expression in Human Osteoarthritis Chondrocytes

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες

Abstract Echinocystic acid (EA), a pentacyclic triterpene isolated from the fruits of *Gleditsia sinensis* Lam, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects. However, the effect of EA on IL-1β-stimulated osteoarthritis chondrocyte has not been reported. The purpose of this study was to assess the effects of EA on IL-1β-stimulated human osteoarthritis chondrocyte. Chondrocytes were stimulated with IL-1β in the absence or presence of EA. NO and PGE2 production were measured by Griess reagent and ELISA. The expression of COX-2, iN... περισσότερα »

Public health impact of strain specific immunity to Borrelia burgdorferi

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 6 ώρες

Background: Lyme disease, caused by Borrelia burgdorferi, is the most common tick-borne infection in the United States. Although humans can be infected by at least 16 different strains of B. burgdorferi, the overwhelming majority of infections are due to only four strains. It was recently demonstrated that patients who are treated for early Lyme disease develop immunity to the specific strain of B. burgdorferi that caused their infection. The aim of this study is to estimate the reduction in cases of Lyme disease in the United States that may occur as a result of type specific imm... περισσότερα »

NIAC Seminar: Brian Gordon, PhD

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 6 ώρες

[image: Brian Gordon, Ph.D., Instructor in Radiology] Brian Gordon, Ph.D., Instructor in Radiology Dr. Brian Gordon is an Instructor in the Department of Radiology at Washington University School of Medicine, and was previously a postdoctoral fellow in the Department of Psychology. He received his Ph.D. in Psychology from the University of Illinois in 2010 under the supervision of Drs. Monica Fabiani and Gabriele Gratton. Dr. Gordon is currently working in Dr. Tammie Benzinger's Lab, examining how preclinical Alzheimer's disease pathology leads to alterations in both behavior as ... περισσότερα »

2 faculty, alumna sweep evidence-based dentistry awards

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 6 ώρες

Two University of Washington School of Dentistry faculty members and one alumna have received all three of the American Dental Association's (ADA) 2015 Evidence-Based Dentistry (EBD) Faculty and Practice Awards, the ADA has announced. The post 2 faculty, alumna sweep evidence-based dentistry awards appeared first on UW School of Dentistry. from #Dental via ola Kala on Inoreader http://ift.tt/1LXZGdV via IFTTT