Objectives: Innate immune dysfunction after major burn injuries increases the susceptibility to organ failure. Lipid mediators of inflammation resolution, e.g., resolvin D2, have been shown recently to restore neutrophil functionality and reduce mortality rate in a rat model of major burn injury. However, the physiological mechanisms responsible for the benefic activity of resolvin D2 are not well understood. Design: Prospective randomized animal investigation. Setting: Academic research setting. Subjects: Wistar male rats. Interventions: Animals were subjected to a full-thickness burn of 30% total body surface area. Two hours after burn, 25 ng/kg resolvin D2 was administered IV and repeated every day, for 8 days. At day 10 post burn, 2 mg/kg of lipopolysaccharide was administered IV, and the presence of renal and hepatic injuries was evaluated at day 11 post burn by histology, immunohistochemistry, and relevant blood chemistry. Measurements and Main Results: In untreated animals, we found significant tissue damage in the kidneys and liver, consistent with acute tubular necrosis and multifocal necrosis, and changes in blood chemistry, reflecting the deterioration of renal and hepatic functions. We detected less tissue damage and significantly lower values of blood urea nitrogen (26.4 +/- 2.1 vs 36.0 +/- 9.3 mg/dL; p
from #Medicine via ola Kala on Inoreader http://ift.tt/1N8J5oQ
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Οκτωβρίου
(414)
-
▼
Οκτ 28
(41)
- Paula J. Martin. Suzanne Noël: Cosmetic Surgery, ...
- Samuel J. M. M. Alberti (ed.), War, Art and Surger...
- Jens Gründler, Armut und Wahnsinn: 'Arme Irre' un...
- Clare Debenham, Birth Control and the Rights of Wo...
- Julia Skelly, Addiction and British Visual Culture...
- Clinical analysis of patients suffering from chron...
- Place and Response Learning in the Open-field Towe...
- Effects and Mechanisms by Which Hypercapnic Acidos...
- Numerical Modeling of Fluid-Structure Interaction ...
- Screening of presumptive urinary tract infections ...
- Laboratory testing requirements for diagnosis and ...
- Heparinate but not serum tubes are susceptible to ...
- Eryptosis is induced by hyperthermia in hereditary...
- Crystalluria
- In the News: A roundup of news and information fro...
- Prelim
- Mercy Virtual in the News Again
- Reversible Electrochemical Sensor for Detection of...
- Chemo-Enzymatic Synthesis of 13C Labeled Complex N...
- High-Speed, Integrated Ablation Cell and Dual Conc...
- Analysis of cervical resistance during continuous ...
- Functional demonstrations of starch binding domain...
- Thallium-201 is comparable to technetium-99m-sesta...
- Intravenous paracetamol for relief of pain during ...
- Photodynamic Therapy with Blended Conducting Polym...
- Spinal Cord Infarct During Concomitant Circulatory...
- Kidney and Liver Injuries After Major Burns in Rat...
- Incidence and Mortality of Acute Respiratory Distr...
- Trait Anxiety But Not State Anxiety During Critica...
- Endotoxemia Following Multiple Trauma: Risk Factor...
- Failure of Noninvasive Ventilation for De Novo Acu...
- Does Thrombolysis Have a Place in the Cardiopulmon...
- Excellence in Intensive Care Medicine.
- Interleukin-1 Receptor Blockade Is Associated With...
- Recruitment Maneuvers and Positive End-Expiratory ...
- Shared Decision Making in ICUs: An American Colleg...
- Long-Term Outcome Following Tracheostomy in Critic...
- The q-G method : A q-version of the Steepest Desce...
- Characterization of Traveling Wave Ion Mobility Se...
- Silver Coating for High-Mass-Accuracy Imaging Mass...
- Ultrasensitive Detection of Dual Cancer Biomarkers...
-
▼
Οκτ 28
(41)
Αναζήτηση αυτού του ιστολογίου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.