Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness

Using Monte Carlo simulations, the microdosimetric kinetic model (MKM) was applied to three previously published proton relative biological effectiveness (RBE) studies. The MKM fitting was compared to a generic RBE model as a function of dose averaged linear energy transfer (LETD). Analysis of the fittings reveal no clear advantage to using one model over the other and we conclude that both the MKM and LETD based proton RBE models are appropriate.

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