Immunotherapy and Hyperprogression: Unwanted Outcomes, Unclear Mechanism

Hyperprogression (HP) is a recently defined clinical phenomenon in which patients treated with immunotherapy paradoxically exhibit rapid tumor growth. The mechanisms of hyperprogression remain ill-defined, although recent studies in this issue point to a possible role for Fc receptors in this process.

See related article by Lo Russo et al., p. 989

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