The human evolutionary heritage with frequent recent adaptations has affected a trade‐off between offspring variability and cancer resistance. We may learn from cancer‐resistant "living fossil" animals to find tools for cancer prevention and treatment. We thank Dr. Rochelle Buffenstein, Calico Laboratories for permission to show her photo of this naked mole rat.
Abstract
We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade‐off between offspring variability and cancer resistance, and thus favored cancer‐prone individuals. We turn the attention to a factor setting the highly cancer‐resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30‐50 million years ago. Research focusing on DNA stability mechanisms in 'living fossil' animals may help us find tools for cancer prevention and treatment.
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