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Κυριακή 3 Φεβρουαρίου 2019

Donor characteristics, recipient outcomes, and histologic findings of kidney allografts with diffuse donor-derived glomerular fibrin thrombi

Background: Limited data is available regarding whether donor kidneys with diffuse glomerular fibrin thrombi (GFT) are safe to use. In this study, the clincopathologic characteristics of allografts with diffuse donor-derived GFT were examined. Methods: All deceased donor kidney transplant implantation biopsies from our institution between 07/2011 to 02/2018 with diffuse GFT were included. A control group for comparison consisted of all cases with implantation biopsies obtained during the study period without diffuse GFT. Clinical data were extracted from electronic medical records for all study patients, including donor information. Results: Twenty-four recipients received kidneys with diffuse GFT from 16 deceased donors. All donors died from severe head trauma. On average, 79% of glomeruli contained fibrin thrombi. Nineteen cases had subsequent biopsy; all revealed resolution of GFT. Compared to the control group, kidneys with diffuse GFT had longer cold ischemia time (34 versus 27 hours), were more frequently pumped using machine perfusion (100% versus 81%), and recipients experience a higher frequency of delayed graft function (58% versus 27%). Only two grafts with diffuse GFT failed within the first year. Overall graft survival was similar between the diffuse GFT group and control group. Conclusion: Deceased donor kidneys with diffuse GFT appear to be safe to use given that nearly 92% of recipients in this cohort who received such allografts experienced good clinical outcomes. Histologically, GFT demonstrated rapid resolution following transplantation. Interestingly, diffuse GFT only occurred in donors who suffered severe head trauma in this cohort, which may be a predisposing factor. Disclosure: The authors declare no conflicts of interest. Funding: None. Correspondence: Kuang-Yu Jen, MD, PhD, University of California Davis School of Medicine, Department of Pathology and Laboratory Medicine, 4400 V Street, Suite 1224, Sacramento, CA 95817, Phone: (916) 734-2579, Fax: (916) 734-2560, Email: kyjen@ucdavis.edu Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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