Depression: An Overlooked Villain in Autoimmune Hepatitis?

Abstract

We read with great interest the recent article by Wong et al. on the impact of autoimmune hepatitis (AIH) on health‐related quality of life (HRQoL).⁽¹⁾ So far, this issue has been vastly neglected in patients with AIH. Our particular attention has been drawn to data on mood disturbance, particularly depression. This problem is of great importance in patients with AIH, as depression is one of the key factors responsible for nonadherence to therapy, which increases the risk of relapse and disease progression. A considerable proportion of AIH patients are young adults, often on prolonged steroids that are shown to significantly affect mood.

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https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.30568?af=R