Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Here, we describe protocols for the genetic and chemical validation of c-Fos and Dusp1 as a drug target in leukemia using in vitro and in vivo genetic and humanized mouse models. This method can be applied to any target for genetic validation and therapeutic development.

http://bit.ly/2FfhyV7