LncRNA MIR22HG inhibits growth, migration and invasion through regulating miR‐10a‐5p/NCOR2 axis in hepatocellular carcinoma cells

Abstract

Despite the rapidly identified numbers of lncRNAs in human, the exploration on the molecular mechanisms of lncRNAs are largely lagged behind, because the molecular mechanisms of lncRNAs could be various and complex in different conditions. In this study, we found a new molecular mechanism for a versatile molecule, MIR22HG. MIR22HG is a lncRNA that contributes to the initiation and progression of many human cancers, including hepatocellular carcinoma (HCC). We reported that MIR22HG was downregulated in 120 HCC samples compared with adjacent non‐tumor liver tissues. More interestingly, decreased expression of MIR22HG in HCC could predict poor prognosis of HCC patients. Knockdown of MIR22HG promoted the growth, migration and invasion of HCC cells. To explore the molecular mechanism of MIR22HG, we found that MIR22HG functioned as tumor suppressor in hepatocellular carcinoma in part through serving as a competing endogenous RNA to modulate miRNA‐10a‐5p level. Moreover, NCOR2 was verified to act as the downstream target gene of MIR22HG/miR‐10a‐5p. In addition, MIR22HG/ miRNA‐10a‐5p /NCOR2 axis inhibited the activation of the Wnt/β‐catenin pathway. Together, our results demonstrated that MIR22HG inhibited HCC progression in part through miR‐10a‐5p/NCOR2 signaling axis and might act as a new prognostic biomarker for HCC patients.

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