Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity

Avoiding infection as a consequence of immunosuppression following organ transplantation has been elusive. Here, Jayachandran et al. demonstrate that targeting the immunoregulatory protein coronin 1 in mice results in allograft-specific tolerance in the absence of immunosuppression-associated co-morbidities. Coronin 1-deficiency increased cAMP concentrations to suppress allo-specific T cell responses without compromising pathogen-specific immunity and may represent an attractive therapeutic target.

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