Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

Kurtulus et al. examine the dynamics of the effector CD8+ T cell response in the tumor microenvironment in response to checkpoint blockade immunotherapy. Checkpoint blockade induced a shift from naive-like to memory-precursor- and effector-like subsets within PD-1−CD8+ T cells in tumors. The memory-precursor-like subset is maintained by the transcriptional regulator Tcf7/Tcf1, which is required for efficacy of checkpoint blockade and other immunotherapies.

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