Single-institution experience in 3D MRI-based brachytherapy for cervical cancer for 239 women: can dose overcome poor response?

Dose escalation has been suggested to improve outcomes in locally-advanced cervical cancer. We analyzed our institutional outcomes for women with locally advanced disease and evaluated the impact of dose on local control, progression, and survival. We found that, in line with GEC-ESTRO data, higher doses numerically but not statistically improve outcomes in women who have the poorest response (HRCTV >40cc) to chemoradiation.

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