Quantifying shear-induced deformation and detachment of individual adherent sickle red blood cells

Vaso-occlusive crisis, a common painful complication of sickle cell disease (SCD), is a complex process triggered by inter-cellular adhesive interactions among blood cells and the endothelium in all human organs, e.g., the oxygen-rich lung as well as hypoxic systems such as liver and kidneys. We present a combined experimental-computational study to quantify the adhesive characteristics of sickle mature erythrocytes (SMEs) and irreversibly-sickled cells (ISCs) under flow conditions mimicking those in post-capillary venules.

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