Investigation of optimal physical parameters for precise proton irradiation of orthotopic tumors in small animals

The emergence of preclinical proton irradiation platforms dedicated to radiobiological studies drives the development of small-animal models, mimicking clinical therapy conditions. Targeted irradiations of small volumes are conditioned by the proton beam physical properties. Based on available proton beam data and Geant4 simulations, the optimal features to correctly deliver the prescribed physical dose in small-animal tumors were determined. In particular cases of millimetric tumors, low energy protons are better suited than protons > 50 MeV.

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