Cellular Plasticity in Intestinal Homeostasis and Disease

Emerging evidence supports a dynamic model of the intestine, where the epithelium can de-differentiate and function as an alternative source of stem cells upon tissue damage and stress. de Sousa e Melo and de Sauvage discuss the mechanistic principles and key players involved in intestinal plasticity as well as potential therapeutic implications of cellular plasticity in regenerative medicine and cancer.

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