Thermodynamic modelling of the statistics of cell spreading on ligand coated elastic substrates

Biological spread cells exist in a perpetually fluctuating state, and therefore cannot be described in terms of a unique deterministic system. In order for modelling approaches to provide novel insight and uncover new mechanisms that drive cell behaviour, a framework is required that progresses from traditional deterministic methods (whereby simulation of an experiment predicts a single outcome). In this study we implement a new modelling approach for the analysis of cell spreading on ligand coated substrates, extending the framework for non-equilibrium thermodynamics of cells developed by Shishvan et al.

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