Preservation of Neurocognitive Function (NCF) with Conformal Avoidance of the Hippocampus during Whole-Brain Radiotherapy (HA-WBRT) for Brain Metastases: Preliminary Results of Phase III Trial NRG Oncology CC001

Based on preliminary evidence that radiation to the neuroregenerative hippocampal stem cells plays a role in NCF decline, the phase II NRG/RTOG 0933 trial demonstrated memory-preservation following HA-WBRT. The phase III NRG-CC001 trial of WBRT plus memantine without (WBRT+M) or with hippocampal avoidance (HA-WBRT+M) sought to validate these findings.

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