Abstract
we read with interest the recent report by Hui et al. entitled 'Discordant HER2 immunohistochemical expression and gene amplification in ductal carcinoma in situ – evaluating HER2 in synchronous in situ and invasive carcinoma'.1 This study compares HER2 immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) between admixed synchronous in situ and invasive carcinomas exhibiting an equivocal 2+ HER2 IHC score in the invasive component.
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