Hepatoprotective potential of aqueous extract of Allium eriophyllum Boiss in high-fat diet-induced fatty liver diseases

Abstract

In recent years, Iranian traditional medicine has been used to control, prevent, and treat various diseases such as fatty liver. One of these plants is Allium eriophyllum Boiss. In this research, we assessed the potential of aqueous extract of A. eriophyllum in the treatment of fatty liver disease in Wistar male rats. At beginning of the study, a total of 10 rats were selected as the negative control, and 50 rats were treated with a high-fat diet for 4 months. Then, the animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving the aqueous extract of A. eriophyllum at 25, 50, 100, and 200 mg/kg concentrations. After 2 months, the rats were sacrificed, and blood and liver samples were collected. The data were analyzed by SPSS 21 software. All groups of A. eriophyllum (especially A200) could significantly (p ≤ 0.05) decrease the raised weights of body and liver and the concentrations of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, glucose, and GR and increase the concentrations of HDL, total protein, albumin, SOD, CAT, and GPx as compared to the untreated group. Also, A. eriophyllum (especially A200) decreased the degree of hepatic steatosis as compared to the untreated group. In finally, it appears that the aqueous extract of A. eriophyllum can treat the fatty liver disease in rats.

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