The Importance of Delabeling β-Lactam Allergy in Children

An 11-month-old, previously healthy male infant was diagnosed by his primary care provider with acute otitis media after 2 days of fever and irritability. He was prescribed amoxicillin 90 mg/kg/day for a 10-day course. This course of antibiotics was his first. On day 4, the child developed maculopapular exanthem approximately 5 hours after a dose of amoxicillin (Figure 1; available at www.jpeds.com). There was no associated angioedema, vomiting, diarrhea, or respiratory symptoms. There was no associated high fever, skin sloughing, joint swelling, hematuria, or other systemic symptoms.

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