Pico-Newton mechanical forces promote neurite growth

Investigations over half a century have indicated that mechanical forces induce neurite growth - with neurites elongating at a rate of 0.1-0.3 μm h-1 pN-1, when mechanical force exceeds a threshold, with this being identified as 400-1000 pN for neurites of PC12 cells. In this communication, we demonstrate that neurite elongation of PC12 cells proceeds at the same previously identified rate, on application of mechanical tension of ∼ 1 pN, which is significantly lower than the force generated in-vivo by axons and growth cones.

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