Microtubule feedback and LET-99-dependent control of pulling forces ensure robust spindle position.

During asymmetric division of Caenorhabditis elegans zygote, to properly distribute cell fate determinants, the mitotic spindle is asymmetrically localized by a combination of centering and cortical pulling microtubule-mediated forces, the dynamics of the latter being regulated by mitotic progression. Here we show a novel and additional regulation of these forces by spindle position itself. For that, we observed the onset of transverse spindle oscillations which reflects the burst of anaphase pulling forces.

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