DVH-based Inverse Planning using Monte Carlo Dosimetry for LDR Prostate Brachytherapy

We proposed an inverse planning method based on dose volume histogram optimization and Monte Carlo dosimetry. We compared plans calculated using our proposed method with clinical plans calculated using the TG-43 dosimetry formalism. We demonstrated that our method can provide plans with higher prostate dose homogeneity (up to 6.1%) and lower urethral dose (up to 4.0%) compared to the clinical plans. The computational time (37.5 ± 3.2s) complies with intraoperative time restrictions.

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