ATP Release by Red Blood Cells Under Flow: Model and Simulations

Adenosine Triphosphate (ATP) is a major player as a signaling molecule in blood microcirculation. It is released by red blood cells (RBCs) when they are subjected to shear stresses large enough to induce a sufficient shape deformation. This prominent feature of chemical response to shear stress and RBC deformation constitutes an important link between vessel geometry, flow conditions, and the mechanical properties of RBCs, all contributing factors affecting the chemical signals in the process of vasomotor modulation of the pre-capillary vessel networks.

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