Thick filament extensibility in intact skeletal muscle.

Myofilament extensibility is a key structural parameter for interpreting myosin cross-bridge kinetics in striated muscle. Previous studies reported much higher thick filament extensibility at low tension than the better-known and commonly used values at high tension but in interpreting mechanical studies of muscle, a single value for thick filament extensibility has usually been assumed. Here we established the complete thick filament force-extension curve from actively contracting, intact vertebrate skeletal muscle.

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