Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures

Background and objective

Mixing different drugs for use in continuous infusion systems is a common practice in palliative care, but analytical study of compatibility and stability is not always available. The objective of this work is to study the stability of solutions of ondansetron and haloperidol at different concentrations and temperatures all prepared in 0.9% NaCl and stored in infusors, with all cases protected from light.

Materials and methods

The high performance liquid chromatography-Ultraviolet (HPLC-UV) method was employed for the determination of the drugs. The concentrations of the admixtures were 0.15–0.25 mg/mL and 0.3–0.4 mg/mL of haloperidol and ondansetron, respectively, with a storage temperature of 25°C and 37°C.

Results

All solutions were initially clear and colourless, but visible particles appear, in all cases, into the infusers after 2 days since their preparation.

Conclusion

From the results obtained we can conclude that the mixtures prepared in the conditions previously described are stable less than 48 hours.

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