The FDA approved the BRAF/MEK inhibitor combination encorafenib/binimetinib for patients with metastatic or inoperable melanoma with a BRAF V600E or V600K mutation. The approval was based on results of a phase III trial in which patients treated with the combination had a median progression-free survival of 14.9 months, compared with 7.3 months in a control group that received vemurafenib alone.
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