Two Sides of the Same Coin: Head and Neck Cancer Treatment De-Intensification and Intensification with Induction Chemotherapy

The terms "intensification" and "de-intensification" are ubiquitous in the lexicon of head and neck oncology as the field moves toward individualizing treatment strategies on the basis of clinical factors such as TNM staging and biomarkers such as human papillomavirus (HPV). In this edition of Oncology Scan, we feature 3 articles linked by the theme of induction chemotherapy (IC), a treatment paradigm used for both intensification and de-intensification. The first 2 articles, by Marur et al (1) and Chen et al (2), study HPV-associated oropharyngeal cancer and examine the role of IC to select patients for radiation dose de-escalation.

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