In vitro Activities of the Benzoquinolizine Fluoroquinolone Levonadifloxacin (WCK 771) and Other Antimicrobial Agents Against Human Mycoplasmas and Ureaplasmas Including Isolates with Defined Resistance Mechanisms [PublishAheadOfPrint]

Levonadifloxacin (WCK 771) was evaluated against 68 type strains and clinical isolates of Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae and Ureaplasma species in comparison to moxifloxacin, levofloxacin, tetracycline and azithromycin or clindamycin. Levonadifloxacin MICs were ≤ 0.5 μg/ml for Mycoplasma genitalium. MIC_90s (μg/ml) were 1 (Mycoplasma hominis), 0.125 (Mycoplasma pneumoniae) and 2 (Ureaplasma spp). Levonadifloxacin merits further study for treating infections caused by these organisms.

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