Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development

Matoba et al. show that mouse cloning efficiency can be significantly improved by simultaneously overcoming two reprogramming barriers, Xist and H3K9me3, although efficiency is still low in comparison with IVF. Comprehensive analyses showed that SCNT embryos can have complete loss of H3K27me3 imprinting, likely explaining this low efficiency.

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